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Organochlorine pesticide levels in Greek patients with Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disease, mostly presenting with characteristic motor symptoms. Organochlorines (OC) are a class of widely-used pesticides that have been included among the list of environmental factors incriminated in PD pathogenesis. However, most studies...

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Autores principales: Dardiotis, Efthimios, Aloizou, Athina-Maria, Sakalakis, Evagelos, Siokas, Vasileios, Koureas, Michalis, Xiromerisiou, Georgia, Petinaki, Efthymia, Wilks, Martin, Tsatsakis, Aristidis, Hadjichristodoulou, Christos, Stefanis, Leonidas, Hadjigeorgiou, Georgios M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225589/
https://www.ncbi.nlm.nih.gov/pubmed/32426240
http://dx.doi.org/10.1016/j.toxrep.2020.03.011
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author Dardiotis, Efthimios
Aloizou, Athina-Maria
Sakalakis, Evagelos
Siokas, Vasileios
Koureas, Michalis
Xiromerisiou, Georgia
Petinaki, Efthymia
Wilks, Martin
Tsatsakis, Aristidis
Hadjichristodoulou, Christos
Stefanis, Leonidas
Hadjigeorgiou, Georgios M.
author_facet Dardiotis, Efthimios
Aloizou, Athina-Maria
Sakalakis, Evagelos
Siokas, Vasileios
Koureas, Michalis
Xiromerisiou, Georgia
Petinaki, Efthymia
Wilks, Martin
Tsatsakis, Aristidis
Hadjichristodoulou, Christos
Stefanis, Leonidas
Hadjigeorgiou, Georgios M.
author_sort Dardiotis, Efthimios
collection PubMed
description BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disease, mostly presenting with characteristic motor symptoms. Organochlorines (OC) are a class of widely-used pesticides that have been included among the list of environmental factors incriminated in PD pathogenesis. However, most studies reporting this association are based on questionnaires, and few have reported exposure data. AIM: To examine the relationship between OC blood concentrations and PD risk. METHODS: In the present study, we studied the concentrations of 8 OC compounds (hexachlorobenzene, heptachlor, hepachlor epoxide, c-chlordane, a-chlordane, p,p’-DDE, DDD, DDT) in 104 Greek PD patients and 110 healthy controls. RESULTS: All substances studied were present in at least one sample. The most frequently detected (above the level of quantification) pesticides were p,p’-DDE (n = 214, 100 % of both groups) and hexachlorobenzene, HCB (n = 189, cases 46.5 %, controls 53.5 %). Higher levels of DDE were detected among PD patients in comparison to controls by using logistic regression analysis to control for confounders [Odds Ratio, OR (95 % confidence interval, C.I.)]: 2.592,(1.29–5.21)], whilst lower levels of HCB were detect among PD patients [OR,95 %CI:0.176(0.09−0.35)]. CONCLUSIONS: Our data suggest that exposure to specific OCs is related to the risk of PD. Further studies, using real exposure data, are needed in order to confirm and extend these findings.
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spelling pubmed-72255892020-05-18 Organochlorine pesticide levels in Greek patients with Parkinson’s disease Dardiotis, Efthimios Aloizou, Athina-Maria Sakalakis, Evagelos Siokas, Vasileios Koureas, Michalis Xiromerisiou, Georgia Petinaki, Efthymia Wilks, Martin Tsatsakis, Aristidis Hadjichristodoulou, Christos Stefanis, Leonidas Hadjigeorgiou, Georgios M. Toxicol Rep Regular Article BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disease, mostly presenting with characteristic motor symptoms. Organochlorines (OC) are a class of widely-used pesticides that have been included among the list of environmental factors incriminated in PD pathogenesis. However, most studies reporting this association are based on questionnaires, and few have reported exposure data. AIM: To examine the relationship between OC blood concentrations and PD risk. METHODS: In the present study, we studied the concentrations of 8 OC compounds (hexachlorobenzene, heptachlor, hepachlor epoxide, c-chlordane, a-chlordane, p,p’-DDE, DDD, DDT) in 104 Greek PD patients and 110 healthy controls. RESULTS: All substances studied were present in at least one sample. The most frequently detected (above the level of quantification) pesticides were p,p’-DDE (n = 214, 100 % of both groups) and hexachlorobenzene, HCB (n = 189, cases 46.5 %, controls 53.5 %). Higher levels of DDE were detected among PD patients in comparison to controls by using logistic regression analysis to control for confounders [Odds Ratio, OR (95 % confidence interval, C.I.)]: 2.592,(1.29–5.21)], whilst lower levels of HCB were detect among PD patients [OR,95 %CI:0.176(0.09−0.35)]. CONCLUSIONS: Our data suggest that exposure to specific OCs is related to the risk of PD. Further studies, using real exposure data, are needed in order to confirm and extend these findings. Elsevier 2020-04-08 /pmc/articles/PMC7225589/ /pubmed/32426240 http://dx.doi.org/10.1016/j.toxrep.2020.03.011 Text en © 2020 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Dardiotis, Efthimios
Aloizou, Athina-Maria
Sakalakis, Evagelos
Siokas, Vasileios
Koureas, Michalis
Xiromerisiou, Georgia
Petinaki, Efthymia
Wilks, Martin
Tsatsakis, Aristidis
Hadjichristodoulou, Christos
Stefanis, Leonidas
Hadjigeorgiou, Georgios M.
Organochlorine pesticide levels in Greek patients with Parkinson’s disease
title Organochlorine pesticide levels in Greek patients with Parkinson’s disease
title_full Organochlorine pesticide levels in Greek patients with Parkinson’s disease
title_fullStr Organochlorine pesticide levels in Greek patients with Parkinson’s disease
title_full_unstemmed Organochlorine pesticide levels in Greek patients with Parkinson’s disease
title_short Organochlorine pesticide levels in Greek patients with Parkinson’s disease
title_sort organochlorine pesticide levels in greek patients with parkinson’s disease
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225589/
https://www.ncbi.nlm.nih.gov/pubmed/32426240
http://dx.doi.org/10.1016/j.toxrep.2020.03.011
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