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Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation

Morphine is frequently used for pain relief, but long-term morphine therapy in patients with chronic pain results in analgesic tolerance and hyperalgesia. There are no effective therapeutic treatments that limit these detrimental side effects. We found pretreatment with melatonin could decrease morp...

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Detalles Bibliográficos
Autores principales:	Liu, Qianjin, Su, Ling-Yan, Sun, Chunli, Jiao, Lijin, Miao, Ying, Xu, Min, Luo, Rongcan, Zuo, Xin, Zhou, Rongbin, Zheng, Ping, Xiong, Wei, Xue, Tian, Yao, Yong-Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225735/ https://www.ncbi.nlm.nih.gov/pubmed/32413745 http://dx.doi.org/10.1016/j.redox.2020.101560

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