GPAT4-Generated Saturated LPAs Induce Lipotoxicity through Inhibition of Autophagy by Abnormal Formation of Omegasomes

Excessive levels of saturated fatty acids are toxic to vascular smooth muscle cells (VSMCs). We previously reported that mice lacking VSMC-stearoyl-CoA desaturase (SCD), a major enzyme catalyzing the detoxification of saturated fatty acids, develop severe vascular calcification from the massive accu...

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Detalles Bibliográficos
Autores principales: Shiozaki, Yuji, Miyazaki–Anzai, Shinobu, Okamura, Kayo, Keenan, Audrey L., Masuda, Masashi, Miyazaki, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225743/
https://www.ncbi.nlm.nih.gov/pubmed/32408172
http://dx.doi.org/10.1016/j.isci.2020.101105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225743/
https://www.ncbi.nlm.nih.gov/pubmed/32408172
http://dx.doi.org/10.1016/j.isci.2020.101105

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