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Endocytosis, trafficking and exocytosis of intact full-length botulinum neurotoxin type a in cultured rat neurons
Botulinum toxin A (BoNT/A) is a potent neurotoxin that acts primarily by silencing synaptic transmission by blocking neurotransmitter release. BoNT/A comprises a light chain (LC/A) intracellular protease and a heavy chain (HC/A) composed of a receptor binding domain (HC(C)/A) and a translocation dom...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225749/ https://www.ncbi.nlm.nih.gov/pubmed/32088326 http://dx.doi.org/10.1016/j.neuro.2020.02.009 |