The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment

Pancreatic ductal adenocarcinoma has extremely high malignancy and patients with pancreatic ductal adenocarcinoma have dismal prognosis. The failure of pancreatic ductal adenocarcinoma treatment is largely due to the tumor microenvironment, which is featured by ample stromal cells and complicated ex...

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Detalles Bibliográficos
Autores principales: Sun, Hongzhi, Zhang, Bo, Li, Haijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Special Collection on Local Immunity in the Tumor Microenvironment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225789/
https://www.ncbi.nlm.nih.gov/pubmed/32372692
http://dx.doi.org/10.1177/1533033820920969
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author Sun, Hongzhi
Zhang, Bo
Li, Haijun
author_facet Sun, Hongzhi
Zhang, Bo
Li, Haijun
author_sort Sun, Hongzhi
collection PubMed
description Pancreatic ductal adenocarcinoma has extremely high malignancy and patients with pancreatic ductal adenocarcinoma have dismal prognosis. The failure of pancreatic ductal adenocarcinoma treatment is largely due to the tumor microenvironment, which is featured by ample stromal cells and complicated extracellular matrix. Recent genomic analysis revealed that pancreatic ductal adenocarcinoma harbors frequently mutated genes including KRAS, TP53, CDKN2A, and SMAD4, which can widely alter cellular processes and behaviors. As shown by accumulating studies, these mutant genes may also change tumor microenvironment, which in turn affects pancreatic ductal adenocarcinoma progression. In this review, we summarize the role of such genetic mutations in tumor microenvironment regulation and potential mechanisms.
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spelling pubmed-72257892020-05-20 The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment Sun, Hongzhi Zhang, Bo Li, Haijun Technol Cancer Res Treat Special Collection on Local Immunity in the Tumor Microenvironment Pancreatic ductal adenocarcinoma has extremely high malignancy and patients with pancreatic ductal adenocarcinoma have dismal prognosis. The failure of pancreatic ductal adenocarcinoma treatment is largely due to the tumor microenvironment, which is featured by ample stromal cells and complicated extracellular matrix. Recent genomic analysis revealed that pancreatic ductal adenocarcinoma harbors frequently mutated genes including KRAS, TP53, CDKN2A, and SMAD4, which can widely alter cellular processes and behaviors. As shown by accumulating studies, these mutant genes may also change tumor microenvironment, which in turn affects pancreatic ductal adenocarcinoma progression. In this review, we summarize the role of such genetic mutations in tumor microenvironment regulation and potential mechanisms. SAGE Publications 2020-05-06 /pmc/articles/PMC7225789/ /pubmed/32372692 http://dx.doi.org/10.1177/1533033820920969 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Special Collection on Local Immunity in the Tumor Microenvironment
Sun, Hongzhi
Zhang, Bo
Li, Haijun
The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
title The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
title_full The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
title_fullStr The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
title_full_unstemmed The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
title_short The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
title_sort roles of frequently mutated genes of pancreatic cancer in regulation of tumor microenvironment
topic Special Collection on Local Immunity in the Tumor Microenvironment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225789/
https://www.ncbi.nlm.nih.gov/pubmed/32372692
http://dx.doi.org/10.1177/1533033820920969
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