High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment

OBJECTIVES: HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with integrase inhibitor treatment failure in HIV-1 non-B subtypes....

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Detalles Bibliográficos
Autores principales: El Bouzidi, Kate, Kemp, Steven A, Datir, Rawlings P, Murtala-Ibrahim, Fati, Aliyu, Ahmad, Kwaghe, Vivian, Frampton, Dan, Roy, Sunando, Breuer, Judith, Sabin, Caroline A, Ogbanufe, Obinna, Charurat, Man E, Bonsall, David, Golubchik, Tanya, Fraser, Christophe, Dakum, Patrick, Ndembi, Nicaise, Gupta, Ravindra K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225870/
https://www.ncbi.nlm.nih.gov/pubmed/32105319
http://dx.doi.org/10.1093/jac/dkaa033

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