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Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma

Distant metastases (DM) in head and neck squamous cell carcinoma (HNSCC) remain a challenge as treatment options are limited. To identify biomarkers predictive of DM in primary tumors (PT), gene expression profiling was performed in PT from patients who did, or did not develop DM (T-with and T-witho...

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Autores principales: Alfieri, Salvatore, Carenzo, Andrea, Platini, Francesca, Serafini, Mara S., Perrone, Federica, Galbiati, Donata, Sponghini, Andrea P., Depenni, Roberta, Vingiani, Andrea, Quattrone, Pasquale, Marchesi, Edoardo, Iannó, Maria F., Micali, Arianna, Mancinelli, Elisa, Orlandi, Ester, Marceglia, Sara, Locati, Laura D., Licitra, Lisa, Bossi, Paolo, De Cecco, Loris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225924/
https://www.ncbi.nlm.nih.gov/pubmed/32283719
http://dx.doi.org/10.3390/cancers12040922
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author Alfieri, Salvatore
Carenzo, Andrea
Platini, Francesca
Serafini, Mara S.
Perrone, Federica
Galbiati, Donata
Sponghini, Andrea P.
Depenni, Roberta
Vingiani, Andrea
Quattrone, Pasquale
Marchesi, Edoardo
Iannó, Maria F.
Micali, Arianna
Mancinelli, Elisa
Orlandi, Ester
Marceglia, Sara
Locati, Laura D.
Licitra, Lisa
Bossi, Paolo
De Cecco, Loris
author_facet Alfieri, Salvatore
Carenzo, Andrea
Platini, Francesca
Serafini, Mara S.
Perrone, Federica
Galbiati, Donata
Sponghini, Andrea P.
Depenni, Roberta
Vingiani, Andrea
Quattrone, Pasquale
Marchesi, Edoardo
Iannó, Maria F.
Micali, Arianna
Mancinelli, Elisa
Orlandi, Ester
Marceglia, Sara
Locati, Laura D.
Licitra, Lisa
Bossi, Paolo
De Cecco, Loris
author_sort Alfieri, Salvatore
collection PubMed
description Distant metastases (DM) in head and neck squamous cell carcinoma (HNSCC) remain a challenge as treatment options are limited. To identify biomarkers predictive of DM in primary tumors (PT), gene expression profiling was performed in PT from patients who did, or did not develop DM (T-with and T-without, n = 25 and 24, respectively), and in matched DM. A total of 185 and 42 differentially expressed genes were identified in the T-with vs. T-without and the T-with vs. DM comparisons, respectively. The intersection between these two comparisons identified COX7A1 and TBX5 as common genes. In three independent datasets, both genes were able to significantly distinguish patients according to their DM-free survival. By functional biological analyses, the T-without group showed enrichment in immune-response pathways, whereas the T-with group showed an enrichment in B-plasma cells and Tregs. Increased enrichment of proliferation-related pathways was observed in the T-with group compared with that in the DM group. Further comparisons with/without DM are needed to confirm these data in order to improve clinical management of HNSCC.
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spelling pubmed-72259242020-05-18 Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Alfieri, Salvatore Carenzo, Andrea Platini, Francesca Serafini, Mara S. Perrone, Federica Galbiati, Donata Sponghini, Andrea P. Depenni, Roberta Vingiani, Andrea Quattrone, Pasquale Marchesi, Edoardo Iannó, Maria F. Micali, Arianna Mancinelli, Elisa Orlandi, Ester Marceglia, Sara Locati, Laura D. Licitra, Lisa Bossi, Paolo De Cecco, Loris Cancers (Basel) Article Distant metastases (DM) in head and neck squamous cell carcinoma (HNSCC) remain a challenge as treatment options are limited. To identify biomarkers predictive of DM in primary tumors (PT), gene expression profiling was performed in PT from patients who did, or did not develop DM (T-with and T-without, n = 25 and 24, respectively), and in matched DM. A total of 185 and 42 differentially expressed genes were identified in the T-with vs. T-without and the T-with vs. DM comparisons, respectively. The intersection between these two comparisons identified COX7A1 and TBX5 as common genes. In three independent datasets, both genes were able to significantly distinguish patients according to their DM-free survival. By functional biological analyses, the T-without group showed enrichment in immune-response pathways, whereas the T-with group showed an enrichment in B-plasma cells and Tregs. Increased enrichment of proliferation-related pathways was observed in the T-with group compared with that in the DM group. Further comparisons with/without DM are needed to confirm these data in order to improve clinical management of HNSCC. MDPI 2020-04-09 /pmc/articles/PMC7225924/ /pubmed/32283719 http://dx.doi.org/10.3390/cancers12040922 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alfieri, Salvatore
Carenzo, Andrea
Platini, Francesca
Serafini, Mara S.
Perrone, Federica
Galbiati, Donata
Sponghini, Andrea P.
Depenni, Roberta
Vingiani, Andrea
Quattrone, Pasquale
Marchesi, Edoardo
Iannó, Maria F.
Micali, Arianna
Mancinelli, Elisa
Orlandi, Ester
Marceglia, Sara
Locati, Laura D.
Licitra, Lisa
Bossi, Paolo
De Cecco, Loris
Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma
title Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma
title_full Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma
title_fullStr Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma
title_short Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma
title_sort tumor biomarkers for the prediction of distant metastasis in head and neck squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225924/
https://www.ncbi.nlm.nih.gov/pubmed/32283719
http://dx.doi.org/10.3390/cancers12040922
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