Hyperprogression Under Immune Checkpoint-Based Immunotherapy—Current Understanding, The Role of PD-1/PD-L1 Tumour-Intrinsic Signalling, Future Directions and a Potential Large Animal Model

Immune evasion is a major challenge for the development of successful cancer treatments. One of the known mechanisms is the expression of immune checkpoints (ICs)—proteins regulating the immune cells activation. The advent of immunotherapy using monoclonal antibodies (mAbs) to block the immune check...

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Detalles Bibliográficos
Autores principales: Kocikowski, Mikolaj, Dziubek, Katarzyna, Parys, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226013/
https://www.ncbi.nlm.nih.gov/pubmed/32230745
http://dx.doi.org/10.3390/cancers12040804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226013/
https://www.ncbi.nlm.nih.gov/pubmed/32230745
http://dx.doi.org/10.3390/cancers12040804

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