Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analog...

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Detalles Bibliográficos
Autores principales: Wanat, Weronika, Talma, Michał, Dziuk, Błażej, Pirat, Jean-Luc, Kafarski, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226027/
https://www.ncbi.nlm.nih.gov/pubmed/32283833
http://dx.doi.org/10.3390/biom10040579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226027/
https://www.ncbi.nlm.nih.gov/pubmed/32283833
http://dx.doi.org/10.3390/biom10040579

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