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mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma

Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in lower grade gliomas. The neomorphic enzyme activity of IDH mutants leads to tumor formation through epigenetic alteration, dysfunction of dioxygenases, and metabolic reprogramming. However, it remains elusive as to how IDH...

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Detalles Bibliográficos
Autores principales:	Liu, Yang, Lu, Yanxin, Li, Aiguo, Celiku, Orieta, Han, Sue, Qian, Mingyu, Yang, Chunzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226122/ https://www.ncbi.nlm.nih.gov/pubmed/32224866 http://dx.doi.org/10.3390/cancers12040787

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