Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI

Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation employing drug affinity responsive target stabili...

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Detalles Bibliográficos
Autores principales: Kim, Yonghyo, Sugihara, Yutaka, Kim, Tae Young, Cho, Sung Min, Kim, Jin Young, Lee, Ju Yeon, Yoo, Jong Shin, Song, Doona, Han, Gyoonhee, Rezeli, Melinda, Welinder, Charlotte, Appelqvist, Roger, Marko-Varga, György, Kwon, Ho Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226133/
https://www.ncbi.nlm.nih.gov/pubmed/32230857
http://dx.doi.org/10.3390/biom10040508

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