Cargando…

SPH3643: A novel cyclin‐dependent kinase 4/6 inhibitor with good anticancer efficacy and strong blood‐brain barrier permeability

The cyclin‐dependent kinase (CDK)4/6‐cyclin D1‐Rb‐p16/ink4a pathway is responsible for regulating cell progression past the G(1) restriction point during the cell cycle. The development of a majority of human tumors is associated with dysregulation of this pathway, resulting in increased cancer cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, XueMei, Hong, Yuan, Mao, Yu, Chen, Na, Wang, Qian, Wang, Zhe, Zhang, LeDuo, Wang, Li, Shi, Chen, Shi, WeiJun, Ge, Hui, Li, AnDi, Li, Xin, Xia, GuangXin, Liu, YanJun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226180/ https://www.ncbi.nlm.nih.gov/pubmed/32103527 http://dx.doi.org/10.1111/cas.14367

Ejemplares similares

Calmodulin Binding to the 3614–3643 Region of RyR1 Is Not Essential for Excitation–Contraction Coupling in Skeletal Myotubes
por: O'Connell, Kristen M.S., et al.
Publicado: (2002)

Abstract No.: ABS3643: Observation and documentation of minimal cervical spine movement during intubation with The Anesthetist Society (TAS) video laryngoscope
por: Dave, Mangal
Publicado: (2022)

Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
por: Hatoum, Diana, et al.
Publicado: (2017)

Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
por: Bu, Yanhong, et al.
Publicado: (2021)

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer
por: Wu, Jiang‐Ni, et al.
Publicado: (2021)

ARMANDO, a SPH code for CERN
por: Massidda, L
Publicado: (2008)

SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms
por: Wang, Jian, et al.
Publicado: (2018)

Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma
por: Shi, Weiwei, et al.
Publicado: (2020)

The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
por: Jin, Lei, et al.
Publicado: (2016)

Sph2((176–191)) and Sph2((446–459)): Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires
por: Ataides, Laura Sant’Anna, et al.
Publicado: (2023)

Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination
por: Shi, Wen-Na, et al.
Publicado: (2017)

Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
por: Dai, Lan, et al.
Publicado: (2022)

Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster
por: Jin, Qiao, et al.
Publicado: (2023)

Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation
por: Dai, Lan, et al.
Publicado: (2021)

SPH simulation of liquid metal target dynamics
por: Massidda, L, et al.
Publicado: (2010)

Fluid mechanics and the SPH method: theory and applications
por: Violeau, Damien
Publicado: (2012)

Research on rheological behavior of fresh concrete single-cylinder pumping based on SPH-DEM
por: Wu, Wanrong, et al.
Publicado: (2023)

Correction: Zhang, Z.; et al. Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential. Int. J. Mol. Sci. 2019, 20, 3643
por: Zhang, Zhenwu, et al.
Publicado: (2020)

SphK2 over-expression promotes osteosarcoma cell growth
por: Xu, Dawei, et al.
Publicado: (2017)

Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells
por: Lu, Pei-Hua, et al.
Publicado: (2017)

Simulations of clusters using HYDRA: adaptive PPPM+SPH
por: Thomas, P.A.
Publicado: (1994)

Identification of a Serine Proteinase Homolog (Sp-SPH) Involved in Immune Defense in the Mud Crab Scylla paramamosain
por: Zhang, Qiu-xia, et al.
Publicado: (2013)

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk
por: Schiefler, Carlotta, et al.
Publicado: (2014)

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo
por: Xun, Cai, et al.
Publicado: (2015)

Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy
por: Dong, Yuan-Yuan, et al.
Publicado: (2020)

Numerical investigation on the role of check dams with bottom outlets in debris flow mobility by 2D SPH
por: Shi, Hao, et al.
Publicado: (2022)

Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth
por: Jin, Lu, et al.
Publicado: (2023)

Activities of DAPNIA/SPhN in two nucleon emission photoreactions
por: Laget, J M
Publicado: (1995)

An SPH Approach for Non-Spherical Particles Immersed in Newtonian Fluids
por: Kijanski, Nadine, et al.
Publicado: (2020)

Virtual Experiments of Particle Mixing Process with the SPH-DEM Model
por: Zhu, Siyu, et al.
Publicado: (2021)

A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain
por: Liu, Baowen, et al.
Publicado: (2023)

Selective formation of [Au(23)(SPh(t)Bu)(17)](0), [Au(26)Pd(SPh(t)Bu)(20)](0) and [Au(24)Pt(SC(2)H(4)Ph)(7)(SPh(t)Bu)(11)](0) by controlling ligand-exchange reaction
por: Negishi, Yuichi, et al.
Publicado: (2022)

Microscopic and Macroscopic Fragmentation Characteristics under Hypervelocity Impact Based on MD and SPH Method
por: Wu, Wei-Dong, et al.
Publicado: (2021)

PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats
por: Qiao, Li-fen, et al.
Publicado: (2008)

SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation
por: Yuan, Feifei, et al.
Publicado: (2022)

Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2
por: Morales-Sánchez, Viridiana, et al.
Publicado: (2021)

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2
por: Xiao, Geqiong, et al.
Publicado: (2018)

Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction
por: Wu, Xiaokui, et al.
Publicado: (2022)

MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1
por: Zhang, Hanwen, et al.
Publicado: (2013)

Cyclins in breast cancer: too much of a good thing
por: Enders, Greg H
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_v2gb4p77dfrqvct0tvpofqhrfq