Cargando…

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease

Accumulating evidence points to a link between circadian clock dysfunction and the molecular events that drive tumorigenesis. Here, we investigated the connection between the circadian clock and the hallmarks of cancer in an in vitro model of colorectal cancer (CRC). We used a cross-platform data no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yalçin, Müge, El-Athman, Rukeia, Ouk, Koliane, Priller, Josef, Relógio, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226183/ https://www.ncbi.nlm.nih.gov/pubmed/32295075 http://dx.doi.org/10.3390/cancers12040963

Ejemplares similares

A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer
por: El-Athman, Rukeia, et al.
Publicado: (2018)

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events
por: El-Athman, Rukeia, et al.
Publicado: (2019)

Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease
por: Ouk, Koliane, et al.
Publicado: (2016)

Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol
por: Yalçin, Müge, et al.
Publicado: (2023)

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
por: Fuhr, Luise, et al.
Publicado: (2018)

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease
por: Ouk, Koliane, et al.
Publicado: (2016)

Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells
por: Li, Yin, et al.
Publicado: (2020)

Differential expression of the circadian clock network correlates with tumour progression in gliomas
por: Petkovic, Marina, et al.
Publicado: (2023)

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day
por: Basti, Alireza, et al.
Publicado: (2021)

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes
por: Fuhr, Luise, et al.
Publicado: (2019)

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
por: El-Athman, Rukeia, et al.
Publicado: (2017)

TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment
por: Dose, Benjamin, et al.
Publicado: (2023)

Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol
por: Ludwig, Marius, et al.
Publicado: (2023)

Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light
por: Ouk, Koliane, et al.
Publicado: (2019)

Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes
por: Malhan, Deeksha, et al.
Publicado: (2022)

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
por: Fuhr, Luise, et al.
Publicado: (2022)

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer
por: Hesse, Janina, et al.
Publicado: (2021)

A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes
por: Yalçin, Müge, et al.
Publicado: (2021)

An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling
por: Hesse, Janina, et al.
Publicado: (2020)

The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics
por: Cash, Elizabeth, et al.
Publicado: (2021)

Genetic and biological hallmarks of colorectal cancer
por: Li, Jiexi, et al.
Publicado: (2021)

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health
por: Yalçin, Müge, et al.
Publicado: (2022)

Lipid droplets: platforms with multiple functions in cancer hallmarks
por: Cruz, André L. S., et al.
Publicado: (2020)

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
por: Malhan, Deeksha, et al.
Publicado: (2023)

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer
por: De Palma, Fatima Domenica Elisa, et al.
Publicado: (2019)

Hallmarks of cancer and hallmarks of aging
por: Blagosklonny, Mikhail V.
Publicado: (2022)

Circadian systems biology: When time matters
por: Fuhr, Luise, et al.
Publicado: (2015)

HypoxaMIRs: Key Regulators of Hallmarks of Colorectal Cancer
por: Coronel-Hernández, Jossimar, et al.
Publicado: (2022)

CK2 and the Hallmarks of Cancer
por: Firnau, May-Britt, et al.
Publicado: (2022)

An integrative mathematical model for timing treatment toxicity and Zeitgeber impact in colorectal cancer cells
por: Hesse, Janina, et al.
Publicado: (2023)

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease
por: Fernández-García, S., et al.
Publicado: (2020)

Circadian regulation in aging: Implications for spaceflight and life on earth
por: Malhan, Deeksha, et al.
Publicado: (2023)

Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer
por: Hoskin, Ashley J., et al.
Publicado: (2023)

Ras-Mediated Deregulation of the Circadian Clock in Cancer
por: Relógio, Angela, et al.
Publicado: (2014)

A Pan-Cancer Atlas of Differentially Interacting Hallmarks of Cancer Proteins
por: Kori, Medi, et al.
Publicado: (2022)

Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm
por: Parascandolo, Alessia, et al.
Publicado: (2020)

Sleep Disorders and Circadian Disruption in Huntington’s Disease
por: Saade-Lemus, Sandra, et al.
Publicado: (2023)

Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer
por: Salita, Timothy, et al.
Publicado: (2022)

Hallmarks of glycosylation in cancer
por: Munkley, Jennifer, et al.
Publicado: (2016)

Melatonin and Cancer Hallmarks
por: Talib, Wamidh H.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i1jcm3li5md6ff3ial7nmko9r5