Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control

Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell,...

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Autores principales: Mordovkina, Daria, Lyabin, Dmitry N., Smolin, Egor A., Sogorina, Ekaterina M., Ovchinnikov, Lev P., Eliseeva, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226217/
https://www.ncbi.nlm.nih.gov/pubmed/32290447
http://dx.doi.org/10.3390/biom10040591
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author Mordovkina, Daria
Lyabin, Dmitry N.
Smolin, Egor A.
Sogorina, Ekaterina M.
Ovchinnikov, Lev P.
Eliseeva, Irina
author_facet Mordovkina, Daria
Lyabin, Dmitry N.
Smolin, Egor A.
Sogorina, Ekaterina M.
Ovchinnikov, Lev P.
Eliseeva, Irina
author_sort Mordovkina, Daria
collection PubMed
description Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed.
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spelling pubmed-72262172020-05-18 Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control Mordovkina, Daria Lyabin, Dmitry N. Smolin, Egor A. Sogorina, Ekaterina M. Ovchinnikov, Lev P. Eliseeva, Irina Biomolecules Review Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed. MDPI 2020-04-11 /pmc/articles/PMC7226217/ /pubmed/32290447 http://dx.doi.org/10.3390/biom10040591 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mordovkina, Daria
Lyabin, Dmitry N.
Smolin, Egor A.
Sogorina, Ekaterina M.
Ovchinnikov, Lev P.
Eliseeva, Irina
Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control
title Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control
title_full Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control
title_fullStr Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control
title_full_unstemmed Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control
title_short Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control
title_sort y-box binding proteins in mrnp assembly, translation, and stability control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226217/
https://www.ncbi.nlm.nih.gov/pubmed/32290447
http://dx.doi.org/10.3390/biom10040591
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