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Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma

Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluat...

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Detalles Bibliográficos
Autores principales: Koike, Kazushige, Dehari, Hironari, Shimizu, Shota, Nishiyama, Koyo, Sonoda, Tomoko, Ogi, Kazuhiro, Kobayashi, Junichi, Sasaki, Takanori, Sasaya, Takashi, Tsuchihashi, Kei, Tsukahara, Tomohide, Hasegawa, Tadashi, Torigoe, Toshihiko, Hiratsuka, Hiroyoshi, Miyazaki, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226222/
https://www.ncbi.nlm.nih.gov/pubmed/32167621
http://dx.doi.org/10.1111/cas.14388
Descripción
Sumario:Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluated the association between its expression pattern and histopathological status in 137 cases with OSCC. Human leukocyte antigen class Ⅰ expression was graded semiquantitatively as high, low, and negative. At the invasive front of the tumor, HLA class I expression was high in 72 cases (52.6%), low in 44 cases (32.1%), and negative in 21 cases (15.3%). The HLA class I expression in the tumor center was high in 48 cases (35.0%), low in 58 cases (42.4%), and negative in 31 cases (22.6%). The 5‐year overall survival and disease‐specific survival rates were good in cases with high HLA class I expression at the invasive front; however, there was no significant difference in survival based on HLA class I expression in the tumor center. In addition, high HLA class I expression was correlated with high CD8(+) T cell density, whereas negative HLA class I expression was correlated with low CD8(+) T cell density at the invasive front. These results suggest that it is easier for CD8(+) T cells to recognize presented peptides in the case of high HLA class Ⅰ expression at the tumor invasive front and could be a prognostic factor for OSCC.