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Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma
Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluat...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226222/ https://www.ncbi.nlm.nih.gov/pubmed/32167621 http://dx.doi.org/10.1111/cas.14388 |
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author | Koike, Kazushige Dehari, Hironari Shimizu, Shota Nishiyama, Koyo Sonoda, Tomoko Ogi, Kazuhiro Kobayashi, Junichi Sasaki, Takanori Sasaya, Takashi Tsuchihashi, Kei Tsukahara, Tomohide Hasegawa, Tadashi Torigoe, Toshihiko Hiratsuka, Hiroyoshi Miyazaki, Akihiro |
author_facet | Koike, Kazushige Dehari, Hironari Shimizu, Shota Nishiyama, Koyo Sonoda, Tomoko Ogi, Kazuhiro Kobayashi, Junichi Sasaki, Takanori Sasaya, Takashi Tsuchihashi, Kei Tsukahara, Tomohide Hasegawa, Tadashi Torigoe, Toshihiko Hiratsuka, Hiroyoshi Miyazaki, Akihiro |
author_sort | Koike, Kazushige |
collection | PubMed |
description | Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluated the association between its expression pattern and histopathological status in 137 cases with OSCC. Human leukocyte antigen class Ⅰ expression was graded semiquantitatively as high, low, and negative. At the invasive front of the tumor, HLA class I expression was high in 72 cases (52.6%), low in 44 cases (32.1%), and negative in 21 cases (15.3%). The HLA class I expression in the tumor center was high in 48 cases (35.0%), low in 58 cases (42.4%), and negative in 31 cases (22.6%). The 5‐year overall survival and disease‐specific survival rates were good in cases with high HLA class I expression at the invasive front; however, there was no significant difference in survival based on HLA class I expression in the tumor center. In addition, high HLA class I expression was correlated with high CD8(+) T cell density, whereas negative HLA class I expression was correlated with low CD8(+) T cell density at the invasive front. These results suggest that it is easier for CD8(+) T cells to recognize presented peptides in the case of high HLA class Ⅰ expression at the tumor invasive front and could be a prognostic factor for OSCC. |
format | Online Article Text |
id | pubmed-7226222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72262222020-05-18 Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma Koike, Kazushige Dehari, Hironari Shimizu, Shota Nishiyama, Koyo Sonoda, Tomoko Ogi, Kazuhiro Kobayashi, Junichi Sasaki, Takanori Sasaya, Takashi Tsuchihashi, Kei Tsukahara, Tomohide Hasegawa, Tadashi Torigoe, Toshihiko Hiratsuka, Hiroyoshi Miyazaki, Akihiro Cancer Sci Original Articles Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluated the association between its expression pattern and histopathological status in 137 cases with OSCC. Human leukocyte antigen class Ⅰ expression was graded semiquantitatively as high, low, and negative. At the invasive front of the tumor, HLA class I expression was high in 72 cases (52.6%), low in 44 cases (32.1%), and negative in 21 cases (15.3%). The HLA class I expression in the tumor center was high in 48 cases (35.0%), low in 58 cases (42.4%), and negative in 31 cases (22.6%). The 5‐year overall survival and disease‐specific survival rates were good in cases with high HLA class I expression at the invasive front; however, there was no significant difference in survival based on HLA class I expression in the tumor center. In addition, high HLA class I expression was correlated with high CD8(+) T cell density, whereas negative HLA class I expression was correlated with low CD8(+) T cell density at the invasive front. These results suggest that it is easier for CD8(+) T cells to recognize presented peptides in the case of high HLA class Ⅰ expression at the tumor invasive front and could be a prognostic factor for OSCC. John Wiley and Sons Inc. 2020-04-15 2020-05 /pmc/articles/PMC7226222/ /pubmed/32167621 http://dx.doi.org/10.1111/cas.14388 Text en © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Koike, Kazushige Dehari, Hironari Shimizu, Shota Nishiyama, Koyo Sonoda, Tomoko Ogi, Kazuhiro Kobayashi, Junichi Sasaki, Takanori Sasaya, Takashi Tsuchihashi, Kei Tsukahara, Tomohide Hasegawa, Tadashi Torigoe, Toshihiko Hiratsuka, Hiroyoshi Miyazaki, Akihiro Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma |
title | Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma |
title_full | Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma |
title_fullStr | Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma |
title_full_unstemmed | Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma |
title_short | Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma |
title_sort | prognostic value of hla class i expression in patients with oral squamous cell carcinoma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226222/ https://www.ncbi.nlm.nih.gov/pubmed/32167621 http://dx.doi.org/10.1111/cas.14388 |
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