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H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects
We have been studying the general aspects of the functions of H(2)S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years. Our aim has been to elucidate novel physiological and pathological functions of H(2)S and polysulfides, and unravel the regulation of the enzy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226236/ https://www.ncbi.nlm.nih.gov/pubmed/32326219 http://dx.doi.org/10.3390/biom10040640 |
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author | Nagahara, Noriyuki Wróbel, Maria |
author_facet | Nagahara, Noriyuki Wróbel, Maria |
author_sort | Nagahara, Noriyuki |
collection | PubMed |
description | We have been studying the general aspects of the functions of H(2)S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years. Our aim has been to elucidate novel physiological and pathological functions of H(2)S and polysulfides, and unravel the regulation of the enzymes involved in their biosynthesis, including cystathionine β-synthase (EC 4.2.1.22), cystathionine γ-lyase (EC 4.4.1.1), thiosulfate sulfurtransferase (rhodanese, EC 2.8.1.1), and 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2). Physiological and pathological functions, alternative biosynthetic processes, and additional functions of H(2)S and polysulfides have been reported. Further, the structure and reaction mechanisms of related enzymes have also been reported. We expect this issue to advance scientific knowledge regarding the detailed functions of H(2)S and polysulfides as well as the general properties and regulation of the enzymes involved in their metabolism. We would like to cover four topics: the physiological and pathological functions of H(2)S and polysulfides, the mechanisms of the biosynthesis of H(2)S and polysulfides, the properties of the biosynthetic enzymes, and the regulation of enzymatic activity. The knockout mouse technique is a useful tool to determine new physiological functions, especially those of H(2)S and polysulfides. In the future, we shall take a closer look at symptoms in the human congenital deficiency of each enzyme. Further studies on the regulation of enzymatic activity by in vivo substances may be the key to finding new functions of H(2)S and polysulfides. |
format | Online Article Text |
id | pubmed-7226236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72262362020-05-18 H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects Nagahara, Noriyuki Wróbel, Maria Biomolecules Editorial We have been studying the general aspects of the functions of H(2)S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years. Our aim has been to elucidate novel physiological and pathological functions of H(2)S and polysulfides, and unravel the regulation of the enzymes involved in their biosynthesis, including cystathionine β-synthase (EC 4.2.1.22), cystathionine γ-lyase (EC 4.4.1.1), thiosulfate sulfurtransferase (rhodanese, EC 2.8.1.1), and 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2). Physiological and pathological functions, alternative biosynthetic processes, and additional functions of H(2)S and polysulfides have been reported. Further, the structure and reaction mechanisms of related enzymes have also been reported. We expect this issue to advance scientific knowledge regarding the detailed functions of H(2)S and polysulfides as well as the general properties and regulation of the enzymes involved in their metabolism. We would like to cover four topics: the physiological and pathological functions of H(2)S and polysulfides, the mechanisms of the biosynthesis of H(2)S and polysulfides, the properties of the biosynthetic enzymes, and the regulation of enzymatic activity. The knockout mouse technique is a useful tool to determine new physiological functions, especially those of H(2)S and polysulfides. In the future, we shall take a closer look at symptoms in the human congenital deficiency of each enzyme. Further studies on the regulation of enzymatic activity by in vivo substances may be the key to finding new functions of H(2)S and polysulfides. MDPI 2020-04-21 /pmc/articles/PMC7226236/ /pubmed/32326219 http://dx.doi.org/10.3390/biom10040640 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Nagahara, Noriyuki Wróbel, Maria H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects |
title | H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects |
title_full | H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects |
title_fullStr | H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects |
title_full_unstemmed | H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects |
title_short | H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects |
title_sort | h(2)s, polysulfides, and enzymes: physiological and pathological aspects |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226236/ https://www.ncbi.nlm.nih.gov/pubmed/32326219 http://dx.doi.org/10.3390/biom10040640 |
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