xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner

As histone deacetylase inhibitors (HDACIs) have limited efficacy against solid tumors, we investigated whether and how oxidative stress is involved in sensitivity to HDACIs to develop a novel therapeutic option of HDACIs treatment. We first tested whether a reduction of the antioxidant glutathione (...

Descripción completa

Detalles Bibliográficos
Autores principales: Miyamoto, Keiko, Watanabe, Motoki, Boku, Shogen, Sukeno, Mamiko, Morita, Mie, Kondo, Haruhito, Sakaguchi, Koichi, Taguchi, Tetsuya, Sakai, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226257/
https://www.ncbi.nlm.nih.gov/pubmed/32235498
http://dx.doi.org/10.3390/cancers12040827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226257/
https://www.ncbi.nlm.nih.gov/pubmed/32235498
http://dx.doi.org/10.3390/cancers12040827

Ejemplares similares