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The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas represent a heterogeneous group of tumors, increasingly diagnosed in clinical practice. An early differential diagnosis between malignant and benign lesions is crucial to patient management and the choice of surgery or observation. The...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226258/ https://www.ncbi.nlm.nih.gov/pubmed/32230809 http://dx.doi.org/10.3390/cancers12040807 |
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author | Serafini, Simone Sperti, Cosimo Brazzale, Alessandra Rosalba Cecchin, Diego Zucchetta, Pietro Pierobon, Elisa Sefora Ponzoni, Alberto Valmasoni, Michele Moletta, Lucia |
author_facet | Serafini, Simone Sperti, Cosimo Brazzale, Alessandra Rosalba Cecchin, Diego Zucchetta, Pietro Pierobon, Elisa Sefora Ponzoni, Alberto Valmasoni, Michele Moletta, Lucia |
author_sort | Serafini, Simone |
collection | PubMed |
description | Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas represent a heterogeneous group of tumors, increasingly diagnosed in clinical practice. An early differential diagnosis between malignant and benign lesions is crucial to patient management and the choice of surgery or observation. The therapeutic approach is currently based on a patient’s clinical, biochemical, and morphological characteristics. The latest published International Consensus Guidelines (ICG) make no mention of the role of metabolic assessments of IPMNs. The aim of this study was to review the current literature, examining the role of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in IPMN management. An extensive literature review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and 10 articles were analyzed in detail, focusing on the value of PET as opposed to other standard imaging criteria. Data were retrieved on 419 patients. The 18-FDG-PET proved more sensitive, specific, and accurate than the ICG criteria in detecting malignant IPMNs (reaching 80%, 95%, and 87% vs. 67%, 58%, and 63%, respectively). Metabolic assessments may be used as an additional tool for the appropriate management of patients with doubtful imaging findings. |
format | Online Article Text |
id | pubmed-7226258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72262582020-05-18 The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas Serafini, Simone Sperti, Cosimo Brazzale, Alessandra Rosalba Cecchin, Diego Zucchetta, Pietro Pierobon, Elisa Sefora Ponzoni, Alberto Valmasoni, Michele Moletta, Lucia Cancers (Basel) Review Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas represent a heterogeneous group of tumors, increasingly diagnosed in clinical practice. An early differential diagnosis between malignant and benign lesions is crucial to patient management and the choice of surgery or observation. The therapeutic approach is currently based on a patient’s clinical, biochemical, and morphological characteristics. The latest published International Consensus Guidelines (ICG) make no mention of the role of metabolic assessments of IPMNs. The aim of this study was to review the current literature, examining the role of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in IPMN management. An extensive literature review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and 10 articles were analyzed in detail, focusing on the value of PET as opposed to other standard imaging criteria. Data were retrieved on 419 patients. The 18-FDG-PET proved more sensitive, specific, and accurate than the ICG criteria in detecting malignant IPMNs (reaching 80%, 95%, and 87% vs. 67%, 58%, and 63%, respectively). Metabolic assessments may be used as an additional tool for the appropriate management of patients with doubtful imaging findings. MDPI 2020-03-27 /pmc/articles/PMC7226258/ /pubmed/32230809 http://dx.doi.org/10.3390/cancers12040807 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Serafini, Simone Sperti, Cosimo Brazzale, Alessandra Rosalba Cecchin, Diego Zucchetta, Pietro Pierobon, Elisa Sefora Ponzoni, Alberto Valmasoni, Michele Moletta, Lucia The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas |
title | The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas |
title_full | The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas |
title_fullStr | The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas |
title_full_unstemmed | The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas |
title_short | The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas |
title_sort | role of positron emission tomography in clinical management of intraductal papillary mucinous neoplasms of the pancreas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226258/ https://www.ncbi.nlm.nih.gov/pubmed/32230809 http://dx.doi.org/10.3390/cancers12040807 |
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