Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer

The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant sh...

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Detalles Bibliográficos
Autores principales: Koi, Yumiko, Tsutani, Yasuhiro, Nishiyama, Yukie, Kanda, Miyuki, Shiroma, Yoshitomo, Yamamoto, Yuki, Sasada, Shinsuke, Akita, Tomoyuki, Masumoto, Norio, Kadoya, Takayuki, Takahashi, Ryou‐u, Tanaka, Junko, Okada, Morihito, Tahara, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226277/
https://www.ncbi.nlm.nih.gov/pubmed/32249523
http://dx.doi.org/10.1111/cas.14378
Descripción
Sumario:The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant shortening of the median G‐tail length was observed in BC patients compared with cancer‐free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G‐tail length might be a potential biomarker for BC detection.

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