Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer

The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant sh...

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Autores principales: Koi, Yumiko, Tsutani, Yasuhiro, Nishiyama, Yukie, Kanda, Miyuki, Shiroma, Yoshitomo, Yamamoto, Yuki, Sasada, Shinsuke, Akita, Tomoyuki, Masumoto, Norio, Kadoya, Takayuki, Takahashi, Ryou‐u, Tanaka, Junko, Okada, Morihito, Tahara, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226277/
https://www.ncbi.nlm.nih.gov/pubmed/32249523
http://dx.doi.org/10.1111/cas.14378
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author Koi, Yumiko
Tsutani, Yasuhiro
Nishiyama, Yukie
Kanda, Miyuki
Shiroma, Yoshitomo
Yamamoto, Yuki
Sasada, Shinsuke
Akita, Tomoyuki
Masumoto, Norio
Kadoya, Takayuki
Takahashi, Ryou‐u
Tanaka, Junko
Okada, Morihito
Tahara, Hidetoshi
author_facet Koi, Yumiko
Tsutani, Yasuhiro
Nishiyama, Yukie
Kanda, Miyuki
Shiroma, Yoshitomo
Yamamoto, Yuki
Sasada, Shinsuke
Akita, Tomoyuki
Masumoto, Norio
Kadoya, Takayuki
Takahashi, Ryou‐u
Tanaka, Junko
Okada, Morihito
Tahara, Hidetoshi
author_sort Koi, Yumiko
collection PubMed
description The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant shortening of the median G‐tail length was observed in BC patients compared with cancer‐free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G‐tail length might be a potential biomarker for BC detection.
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spelling pubmed-72262772020-05-18 Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer Koi, Yumiko Tsutani, Yasuhiro Nishiyama, Yukie Kanda, Miyuki Shiroma, Yoshitomo Yamamoto, Yuki Sasada, Shinsuke Akita, Tomoyuki Masumoto, Norio Kadoya, Takayuki Takahashi, Ryou‐u Tanaka, Junko Okada, Morihito Tahara, Hidetoshi Cancer Sci Case Report The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant shortening of the median G‐tail length was observed in BC patients compared with cancer‐free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G‐tail length might be a potential biomarker for BC detection. John Wiley and Sons Inc. 2020-04-06 2020-05 /pmc/articles/PMC7226277/ /pubmed/32249523 http://dx.doi.org/10.1111/cas.14378 Text en © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Report
Koi, Yumiko
Tsutani, Yasuhiro
Nishiyama, Yukie
Kanda, Miyuki
Shiroma, Yoshitomo
Yamamoto, Yuki
Sasada, Shinsuke
Akita, Tomoyuki
Masumoto, Norio
Kadoya, Takayuki
Takahashi, Ryou‐u
Tanaka, Junko
Okada, Morihito
Tahara, Hidetoshi
Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
title Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
title_full Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
title_fullStr Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
title_full_unstemmed Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
title_short Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
title_sort diagnostic performance of peripheral leukocyte telomere g‐tail length for detecting breast cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226277/
https://www.ncbi.nlm.nih.gov/pubmed/32249523
http://dx.doi.org/10.1111/cas.14378
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