Cargando…

Antitumor activity of a novel oral signal transducer and activator of transcription 3 inhibitor YHO‐1701

The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival and invasion. Aberrant STAT3 has been demonstrated in various malignant cancers. YHO‐1701 is a novel quinolinecarboxamide derivative generated from STX‐0119. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nishisaka, Fukiko, Taniguchi, Keisuke, Tsugane, Momomi, Hirata, Genya, Takagi, Akimitsu, Asakawa, Naoyuki, Kurita, Akinobu, Takahashi, Hiroyuki, Ogo, Naohisa, Shishido, Yoshiyuki, Asai, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226286/ https://www.ncbi.nlm.nih.gov/pubmed/32112605 http://dx.doi.org/10.1111/cas.14369

Ejemplares similares

Efficacy of combination treatment using YHO-1701, an orally active STAT3 inhibitor, with molecular-targeted agents on cancer cell lines
por: Taniguchi, Keisuke, et al.
Publicado: (2021)

Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure
por: Taniguchi, Keisuke, et al.
Publicado: (2021)

YPC‐21661 and YPC‐22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo
por: Haibara, Hirotaka, et al.
Publicado: (2017)

Sequential Pressure-Induced B1–B2 Transitions in the Anion-Ordered Oxyhydride Ba(2)YHO(3)
por: Morgan, Harry W. T., et al.
Publicado: (2022)

Crespones y campanas tlaxcaltecas en 1701 /
por: González Acosta, Alejandro
Publicado: (2000)

PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse
por: Konishi, Hiroaki, et al.
Publicado: (2012)

WALTER CHARLETON'S `ORATIO ANNIVERSARIA' 1701. LONDON, 1704
Publicado: (1972)

A Table of All the Known Operations of Ovarotomy from 1701 to 1851
Publicado: (1852)

STX‐0119, a novel STAT3 dimerization inhibitor, prevents fibrotic gene expression in a mouse model of kidney fibrosis by regulating Cxcr4 and Ccr1 expression
por: Makitani, Kouki, et al.
Publicado: (2020)

Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma
por: Ribeiro, Marcelo Lima, et al.
Publicado: (2021)

Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities
por: Sawaguchi, Yuichi, et al.
Publicado: (2021)

A GntR Family Transcription Factor (VPA1701) for Swarming Motility and Colonization of Vibrio parahaemolyticus
por: Gu, Dan, et al.
Publicado: (2019)

1701. Trends in Invasive Candidiasis in Children with Hematologic Malignancies: Increased Risk of Dissemination with Non-albicans Candida
por: Said, Amira, et al.
Publicado: (2023)

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity
por: Kashima, Hajime, et al.
Publicado: (2016)

Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors
por: Dotsu, Yosuke, et al.
Publicado: (2022)

Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients
por: Vettori, Erica, et al.
Publicado: (2019)

The impact of peritoneal lavage cytology in biliary tract cancer (KHBO1701): Kansai Hepato‐Biliary Oncology Group
por: Matsukuma, Satoshi, et al.
Publicado: (2020)

Spleen volume-based non-invasive tool for predicting hepatic decompensation in people with compensated cirrhosis (CHESS1701)
por: Yu, Qian, et al.
Publicado: (2022)

Structure and comparison of the motor domain of centromere-associated protein E
por: Shibuya, Asuka, et al.
Publicado: (2021)

Fluidic Active Transducer for Electricity Generation
por: Yang, YoungJun, et al.
Publicado: (2015)

Genomic Characterization of Orf Virus Strain D1701-V (Parapoxvirus) and Development of Novel Sites for Multiple Transgene Expression
por: Rziha, Hanns-Joachim, et al.
Publicado: (2019)

Roy et al. On Two Novel Parameters for Validation of Predictive QSAR Models. Molecules, 2009, 14, 1660-1701
por: Roy, Partha Pratim, et al.
Publicado: (2010)

1701. Differences in Diagnostic Performance of β-d-Glucan Testing in Patients with Varying Degrees of Susceptibility to Invasive Fungal Infections
por: Nham, Eliel, et al.
Publicado: (2019)

P1701: A COMPARATIVE STUDY OF THE IMPACT OF COUNTRIES’ HEALTH EXPENDITURE ON THE DIAGNOSIS EXPERIENCES OF PATIENTS WITH LYMPHOMA AND CLL IN EUROPE
por: Bamigbola, F., et al.
Publicado: (2022)

PPRX-1701, a nanoparticle formulation of 6′-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models
por: Zdioruk, Mykola, et al.
Publicado: (2023)

PB1701: REPLACING THE CURRENT METHODS IN LEUKEMIA DIAGNOSTICS WITH OPTICAL GENOME MAPPING AND CAS9-DIRECTED NANOPORE SEQUENCING.
por: Commandeur-Jan, Sabrina, et al.
Publicado: (2023)

Novel Multiplexed Assay for Identifying SH2 Domain Antagonists of STAT Family Proteins
por: Takakuma, Kazuyuki, et al.
Publicado: (2013)

Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi
por: Okada, Yusuke, et al.
Publicado: (2018)

1054. Activity of a Anti-staphylococcal Lysin, LSVT-1701: In vitro Susceptibility of Staphylococcus aureus and Coagulase-Negative Staphylococci (CoNS) Global Clinical Isolates (2002 to 2019)
por: Huang, David, et al.
Publicado: (2021)

Development and validation of a radiomics signature for clinically significant portal hypertension in cirrhosis (CHESS1701): a prospective multicenter study
por: Liu, Fuquan, et al.
Publicado: (2018)

1701. Pharmacokinetics in Subjects with Renal Impairment in a Contezolid Complicated Skin and Soft Tissue Infection Phase 3 Clinical Trial
por: Fang, Edward, et al.
Publicado: (2022)

Activation of the Transducers of Unfolded Protein Response in Plants
por: Nawkar, Ganesh M., et al.
Publicado: (2018)

Design of an Acoustic Bender Transducer for Active Sonobuoys
por: Pyo, Seonghun, et al.
Publicado: (2019)

MRI-guided percutaneous needle biopsy with 1.2T open MRI: study protocol for a prospective feasibility study (SCIRO-1701)
por: Matsui, Yusuke, et al.
Publicado: (2019)

1701P Oncological patients’ perception of infection risks and level of acceptance of protective measures during SARS-CoV-2 pandemic
por: Tregnago, D., et al.
Publicado: (2020)

Fas transduces activation signals in normal human T lymphocytes
Publicado: (1993)

Signal Transducer and Activator of Transcription 4 in Liver Diseases
por: Wang, Yan, et al.
Publicado: (2015)

Embedded Ultrasonic Transducers for Active and Passive Concrete Monitoring
por: Niederleithinger, Ernst, et al.
Publicado: (2015)

1099. Evaluation of the Safety and Pharmacokinetics (PK) following Administration of Single and Multiple Doses of Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects
por: Wire, Mary Beth, et al.
Publicado: (2021)

Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NFkB activation
por: Ishise, Hisako, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lq1ei06l20u7utjjq5m74cmsci