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Human γδ TCR Repertoires in Health and Disease

The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set...

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Detalles Bibliográficos
Autores principales: Fichtner, Alina Suzann, Ravens, Sarina, Prinz, Immo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226320/
https://www.ncbi.nlm.nih.gov/pubmed/32225004
http://dx.doi.org/10.3390/cells9040800
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author Fichtner, Alina Suzann
Ravens, Sarina
Prinz, Immo
author_facet Fichtner, Alina Suzann
Ravens, Sarina
Prinz, Immo
author_sort Fichtner, Alina Suzann
collection PubMed
description The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2(+) and Vδ1(+) T cells. Of those two subsets, Vδ2(+) T cells seem to better fit into a role of innate T cells with semi-invariant TCR usage, as compared to an adaptive-like biology of some Vδ1(+) subsets. Yet, this distinction into innate-like Vδ2(+) and adaptive-like Vδ1(+) γδ T cells does not quite recapitulate the full diversity of γδ T cell subsets, ligands and interaction modes. Here, we review how the recent introduction of high-throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire diversity beyond Vδ2(+) and Vδ1(+) T cells. We discuss the current understanding of clonal composition and the dynamics of human γδ TCR repertoires in health and disease.
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spelling pubmed-72263202020-05-18 Human γδ TCR Repertoires in Health and Disease Fichtner, Alina Suzann Ravens, Sarina Prinz, Immo Cells Review The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2(+) and Vδ1(+) T cells. Of those two subsets, Vδ2(+) T cells seem to better fit into a role of innate T cells with semi-invariant TCR usage, as compared to an adaptive-like biology of some Vδ1(+) subsets. Yet, this distinction into innate-like Vδ2(+) and adaptive-like Vδ1(+) γδ T cells does not quite recapitulate the full diversity of γδ T cell subsets, ligands and interaction modes. Here, we review how the recent introduction of high-throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire diversity beyond Vδ2(+) and Vδ1(+) T cells. We discuss the current understanding of clonal composition and the dynamics of human γδ TCR repertoires in health and disease. MDPI 2020-03-26 /pmc/articles/PMC7226320/ /pubmed/32225004 http://dx.doi.org/10.3390/cells9040800 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fichtner, Alina Suzann
Ravens, Sarina
Prinz, Immo
Human γδ TCR Repertoires in Health and Disease
title Human γδ TCR Repertoires in Health and Disease
title_full Human γδ TCR Repertoires in Health and Disease
title_fullStr Human γδ TCR Repertoires in Health and Disease
title_full_unstemmed Human γδ TCR Repertoires in Health and Disease
title_short Human γδ TCR Repertoires in Health and Disease
title_sort human γδ tcr repertoires in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226320/
https://www.ncbi.nlm.nih.gov/pubmed/32225004
http://dx.doi.org/10.3390/cells9040800
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