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A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database o...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226323/ https://www.ncbi.nlm.nih.gov/pubmed/32218346 http://dx.doi.org/10.3390/cancers12040783 |
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author | Maulat, Charlotte Canivet, Cindy Touraine, Célia Gourgou, Sophie Napoleon, Bertrand Palazzo, Laurent Flori, Nicolas Piessen, Guillaume Guibert, Pierre Truant, Stéphanie Assenat, Eric Buscail, Louis Bournet, Barbara Muscari, Fabrice |
author_facet | Maulat, Charlotte Canivet, Cindy Touraine, Célia Gourgou, Sophie Napoleon, Bertrand Palazzo, Laurent Flori, Nicolas Piessen, Guillaume Guibert, Pierre Truant, Stéphanie Assenat, Eric Buscail, Louis Bournet, Barbara Muscari, Fabrice |
author_sort | Maulat, Charlotte |
collection | PubMed |
description | Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database on Pancreatic Adenocarcinoma) prospective cohort. Three groups were defined: resectable (Res), locally advanced (LA), and metastatic (Met). Variables were analyzed and a predictive score was devised. Of the 814 patients included, 703 could be evaluated: 164 Res, 266 LA, and 273 Met. The median ages of the patients were 69, 71, and 69, respectively. The median survival times were 21, 15, and nine months, respectively. Six criteria were significantly associated with a lower probability of resectability in multivariate analysis: venous/arterial thrombosis (p = 0.017), performance status 1 (p = 0.032) or ≥ 2 (p = 0.010), pain (p = 0.003), weight loss ≥ 8% (p = 0.019), topography of the tumor (body/tail) (p = 0.005), and maximal tumor size 20–33 mm (p < 0.013) or >33 mm (p < 0.001). The BACAP score was devised using these criteria with an accuracy of 81.17% and an area under the receive operating characteristic (ROC) curve of 0.82 (95% confidence interval (CI): 0.78; 0.86). The presence of pejorative criteria or a BACAP score < 50% indicates that further investigations and even neoadjuvant treatment might be warranted. Trial registration: NCT02818829. |
format | Online Article Text |
id | pubmed-7226323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72263232020-05-18 A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score Maulat, Charlotte Canivet, Cindy Touraine, Célia Gourgou, Sophie Napoleon, Bertrand Palazzo, Laurent Flori, Nicolas Piessen, Guillaume Guibert, Pierre Truant, Stéphanie Assenat, Eric Buscail, Louis Bournet, Barbara Muscari, Fabrice Cancers (Basel) Article Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database on Pancreatic Adenocarcinoma) prospective cohort. Three groups were defined: resectable (Res), locally advanced (LA), and metastatic (Met). Variables were analyzed and a predictive score was devised. Of the 814 patients included, 703 could be evaluated: 164 Res, 266 LA, and 273 Met. The median ages of the patients were 69, 71, and 69, respectively. The median survival times were 21, 15, and nine months, respectively. Six criteria were significantly associated with a lower probability of resectability in multivariate analysis: venous/arterial thrombosis (p = 0.017), performance status 1 (p = 0.032) or ≥ 2 (p = 0.010), pain (p = 0.003), weight loss ≥ 8% (p = 0.019), topography of the tumor (body/tail) (p = 0.005), and maximal tumor size 20–33 mm (p < 0.013) or >33 mm (p < 0.001). The BACAP score was devised using these criteria with an accuracy of 81.17% and an area under the receive operating characteristic (ROC) curve of 0.82 (95% confidence interval (CI): 0.78; 0.86). The presence of pejorative criteria or a BACAP score < 50% indicates that further investigations and even neoadjuvant treatment might be warranted. Trial registration: NCT02818829. MDPI 2020-03-25 /pmc/articles/PMC7226323/ /pubmed/32218346 http://dx.doi.org/10.3390/cancers12040783 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maulat, Charlotte Canivet, Cindy Touraine, Célia Gourgou, Sophie Napoleon, Bertrand Palazzo, Laurent Flori, Nicolas Piessen, Guillaume Guibert, Pierre Truant, Stéphanie Assenat, Eric Buscail, Louis Bournet, Barbara Muscari, Fabrice A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score |
title | A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score |
title_full | A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score |
title_fullStr | A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score |
title_full_unstemmed | A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score |
title_short | A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score |
title_sort | new score to predict the resectability of pancreatic adenocarcinoma: the bacap score |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226323/ https://www.ncbi.nlm.nih.gov/pubmed/32218346 http://dx.doi.org/10.3390/cancers12040783 |
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