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A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score

Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database o...

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Autores principales: Maulat, Charlotte, Canivet, Cindy, Touraine, Célia, Gourgou, Sophie, Napoleon, Bertrand, Palazzo, Laurent, Flori, Nicolas, Piessen, Guillaume, Guibert, Pierre, Truant, Stéphanie, Assenat, Eric, Buscail, Louis, Bournet, Barbara, Muscari, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226323/
https://www.ncbi.nlm.nih.gov/pubmed/32218346
http://dx.doi.org/10.3390/cancers12040783
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author Maulat, Charlotte
Canivet, Cindy
Touraine, Célia
Gourgou, Sophie
Napoleon, Bertrand
Palazzo, Laurent
Flori, Nicolas
Piessen, Guillaume
Guibert, Pierre
Truant, Stéphanie
Assenat, Eric
Buscail, Louis
Bournet, Barbara
Muscari, Fabrice
author_facet Maulat, Charlotte
Canivet, Cindy
Touraine, Célia
Gourgou, Sophie
Napoleon, Bertrand
Palazzo, Laurent
Flori, Nicolas
Piessen, Guillaume
Guibert, Pierre
Truant, Stéphanie
Assenat, Eric
Buscail, Louis
Bournet, Barbara
Muscari, Fabrice
author_sort Maulat, Charlotte
collection PubMed
description Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database on Pancreatic Adenocarcinoma) prospective cohort. Three groups were defined: resectable (Res), locally advanced (LA), and metastatic (Met). Variables were analyzed and a predictive score was devised. Of the 814 patients included, 703 could be evaluated: 164 Res, 266 LA, and 273 Met. The median ages of the patients were 69, 71, and 69, respectively. The median survival times were 21, 15, and nine months, respectively. Six criteria were significantly associated with a lower probability of resectability in multivariate analysis: venous/arterial thrombosis (p = 0.017), performance status 1 (p = 0.032) or ≥ 2 (p = 0.010), pain (p = 0.003), weight loss ≥ 8% (p = 0.019), topography of the tumor (body/tail) (p = 0.005), and maximal tumor size 20–33 mm (p < 0.013) or >33 mm (p < 0.001). The BACAP score was devised using these criteria with an accuracy of 81.17% and an area under the receive operating characteristic (ROC) curve of 0.82 (95% confidence interval (CI): 0.78; 0.86). The presence of pejorative criteria or a BACAP score < 50% indicates that further investigations and even neoadjuvant treatment might be warranted. Trial registration: NCT02818829.
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spelling pubmed-72263232020-05-18 A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score Maulat, Charlotte Canivet, Cindy Touraine, Célia Gourgou, Sophie Napoleon, Bertrand Palazzo, Laurent Flori, Nicolas Piessen, Guillaume Guibert, Pierre Truant, Stéphanie Assenat, Eric Buscail, Louis Bournet, Barbara Muscari, Fabrice Cancers (Basel) Article Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database on Pancreatic Adenocarcinoma) prospective cohort. Three groups were defined: resectable (Res), locally advanced (LA), and metastatic (Met). Variables were analyzed and a predictive score was devised. Of the 814 patients included, 703 could be evaluated: 164 Res, 266 LA, and 273 Met. The median ages of the patients were 69, 71, and 69, respectively. The median survival times were 21, 15, and nine months, respectively. Six criteria were significantly associated with a lower probability of resectability in multivariate analysis: venous/arterial thrombosis (p = 0.017), performance status 1 (p = 0.032) or ≥ 2 (p = 0.010), pain (p = 0.003), weight loss ≥ 8% (p = 0.019), topography of the tumor (body/tail) (p = 0.005), and maximal tumor size 20–33 mm (p < 0.013) or >33 mm (p < 0.001). The BACAP score was devised using these criteria with an accuracy of 81.17% and an area under the receive operating characteristic (ROC) curve of 0.82 (95% confidence interval (CI): 0.78; 0.86). The presence of pejorative criteria or a BACAP score < 50% indicates that further investigations and even neoadjuvant treatment might be warranted. Trial registration: NCT02818829. MDPI 2020-03-25 /pmc/articles/PMC7226323/ /pubmed/32218346 http://dx.doi.org/10.3390/cancers12040783 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maulat, Charlotte
Canivet, Cindy
Touraine, Célia
Gourgou, Sophie
Napoleon, Bertrand
Palazzo, Laurent
Flori, Nicolas
Piessen, Guillaume
Guibert, Pierre
Truant, Stéphanie
Assenat, Eric
Buscail, Louis
Bournet, Barbara
Muscari, Fabrice
A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
title A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
title_full A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
title_fullStr A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
title_full_unstemmed A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
title_short A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
title_sort new score to predict the resectability of pancreatic adenocarcinoma: the bacap score
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226323/
https://www.ncbi.nlm.nih.gov/pubmed/32218346
http://dx.doi.org/10.3390/cancers12040783
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