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Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device

Cold atmospheric plasma (CAP) treatment is developing as a promising option for local anti-neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Currently, high-frequency electrosurgical argon plasma sources are available and well established for clinical use. In this study, w...

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Autores principales: Feil, Lukas, Koch, André, Utz, Raphael, Ackermann, Michael, Barz, Jakob, Stope, Matthias, Krämer, Bernhard, Wallwiener, Diethelm, Brucker, Sara Y., Weiss, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226384/
https://www.ncbi.nlm.nih.gov/pubmed/32340164
http://dx.doi.org/10.3390/cancers12041037
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author Feil, Lukas
Koch, André
Utz, Raphael
Ackermann, Michael
Barz, Jakob
Stope, Matthias
Krämer, Bernhard
Wallwiener, Diethelm
Brucker, Sara Y.
Weiss, Martin
author_facet Feil, Lukas
Koch, André
Utz, Raphael
Ackermann, Michael
Barz, Jakob
Stope, Matthias
Krämer, Bernhard
Wallwiener, Diethelm
Brucker, Sara Y.
Weiss, Martin
author_sort Feil, Lukas
collection PubMed
description Cold atmospheric plasma (CAP) treatment is developing as a promising option for local anti-neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Currently, high-frequency electrosurgical argon plasma sources are available and well established for clinical use. In this study, we investigated the effects of treatment with a non-thermally operated electrosurgical argon plasma source, a Martin Argon Plasma Beamer System (MABS), on cell proliferation and metabolism of a tissue panel of human cervical cancer cell lines as well as on non-cancerous primary cells of the cervix uteri. Similar to conventional CAP sources, we were able to show that MABS was capable of causing antiproliferative and cytotoxic effects on cervical squamous cell and adenocarcinoma as well as on non-neoplastic cervical tissue cells due to the generation of reactive species. Notably, neoplastic cells were more sensitive to the MABS treatment, suggesting a promising new and non-invasive application for in vivo treatment of precancerous and cancerous cervical lesions with non-thermally operated electrosurgical argon plasma sources.
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spelling pubmed-72263842020-05-18 Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device Feil, Lukas Koch, André Utz, Raphael Ackermann, Michael Barz, Jakob Stope, Matthias Krämer, Bernhard Wallwiener, Diethelm Brucker, Sara Y. Weiss, Martin Cancers (Basel) Article Cold atmospheric plasma (CAP) treatment is developing as a promising option for local anti-neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Currently, high-frequency electrosurgical argon plasma sources are available and well established for clinical use. In this study, we investigated the effects of treatment with a non-thermally operated electrosurgical argon plasma source, a Martin Argon Plasma Beamer System (MABS), on cell proliferation and metabolism of a tissue panel of human cervical cancer cell lines as well as on non-cancerous primary cells of the cervix uteri. Similar to conventional CAP sources, we were able to show that MABS was capable of causing antiproliferative and cytotoxic effects on cervical squamous cell and adenocarcinoma as well as on non-neoplastic cervical tissue cells due to the generation of reactive species. Notably, neoplastic cells were more sensitive to the MABS treatment, suggesting a promising new and non-invasive application for in vivo treatment of precancerous and cancerous cervical lesions with non-thermally operated electrosurgical argon plasma sources. MDPI 2020-04-23 /pmc/articles/PMC7226384/ /pubmed/32340164 http://dx.doi.org/10.3390/cancers12041037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feil, Lukas
Koch, André
Utz, Raphael
Ackermann, Michael
Barz, Jakob
Stope, Matthias
Krämer, Bernhard
Wallwiener, Diethelm
Brucker, Sara Y.
Weiss, Martin
Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device
title Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device
title_full Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device
title_fullStr Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device
title_full_unstemmed Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device
title_short Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device
title_sort cancer-selective treatment of cancerous and non-cancerous human cervical cell models by a non-thermally operated electrosurgical argon plasma device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226384/
https://www.ncbi.nlm.nih.gov/pubmed/32340164
http://dx.doi.org/10.3390/cancers12041037
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