Cargando…

TERT Promoter Mutations Differently Correlate with the Clinical Outcome of MAPK Inhibitor-Treated Melanoma Patients

Resistance is a major challenge in the management of mitogen-activated protein kinase inhibitor (MAPKi)-treated metastatic melanoma. Tumor genetic alterations can cause MAPK pathway reactivation, leading to lack of response and poor outcome. Characterization of the mutational profile in patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Del Bianco, Paola, Stagni, Camilla, Giunco, Silvia, Fabozzi, Alessio, Elefanti, Lisa, Pellegrini, Stefania, Vecchiato, Antonella, Pigozzo, Jacopo, Zamuner, Carolina, De Rossi, Anita, De Nicolo, Arcangela, Menin, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226422/ https://www.ncbi.nlm.nih.gov/pubmed/32290374 http://dx.doi.org/10.3390/cancers12040946

Ejemplares similares

Genetic Variants of the TERT Gene, Telomere Length, and Circulating TERT as Prognostic Markers in Rectal Cancer Patients
por: Rampazzo, Enrica, et al.
Publicado: (2020)

The Interplay between Nevi and Melanoma Predisposition Unravels Nevi-Related and Nevi-Resistant Familial Melanoma
por: Pellegrini, Stefania, et al.
Publicado: (2021)

The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI)
por: Elefanti, Lisa, et al.
Publicado: (2021)

Prognostic Factors in Merkel Cell Carcinoma: A Retrospective Single-Center Study in 90 Patients
por: Rastrelli, Marco, et al.
Publicado: (2018)

Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells
por: Celeghin, Andrea, et al.
Publicado: (2016)

Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus
por: Giunco, S, et al.
Publicado: (2015)

TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
por: Vallarelli, Andrelou F., et al.
Publicado: (2016)

Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach
por: Amin, Aamir, et al.
Publicado: (2023)

The immune cell landscape of metastatic uveal melanoma correlates with overall survival
por: Tosi, Anna, et al.
Publicado: (2021)

Biological Predictors of De Novo Tumors in Solid Organ Transplanted Patients During Oncological Surveillance: Potential Role of Circulating TERT mRNA
por: Cangemi, Michela, et al.
Publicado: (2021)

Molecular Modeling Unveils the Effective Interaction of B-RAF Inhibitors with Rare B-RAF Insertion Variants
por: Scaini, Maria Chiara, et al.
Publicado: (2023)

Per- and polyfluoroalkyl substances (PFAS) exposure in melanoma patients: a retrospective study on prognosis and histological features
por: Del Fiore, Paolo, et al.
Publicado: (2022)

TERT Promoter Mutation as an Independent Prognostic Marker for Poor Prognosis MAPK Inhibitors-Treated Melanoma
por: Blateau, Pauline, et al.
Publicado: (2020)

The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid Organelle
por: Joukov, Vladimir, et al.
Publicado: (2019)

Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patients
por: Giunco, S., et al.
Publicado: (2023)

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications
por: Giunco, Silvia, et al.
Publicado: (2018)

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients
por: Rampazzo, Enrica, et al.
Publicado: (2018)

TERT Promoter Mutations and rs2853669 Polymorphism: Useful Markers for Clinical Outcome Stratification of Patients With Oral Cavity Squamous Cell Carcinoma
por: Giunco, Silvia, et al.
Publicado: (2021)

Immune senescence and immune activation in elderly colorectal cancer patients
por: Giunco, Silvia, et al.
Publicado: (2019)

Consolidation electrochemotherapy with bleomycin in metastatic melanoma during treatment with dabrafenib
por: Valpione, Sara, et al.
Publicado: (2015)

Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients
por: Rampazzo, Enrica, et al.
Publicado: (2018)

Melanoma in Adolescents and Young Adults: Evaluation of the Characteristics, Treatment Strategies, and Prognostic Factors in a Monocentric Retrospective Study
por: Del Fiore, Paolo, et al.
Publicado: (2021)

Corrigendum: Melanoma in Adolescents and Young Adults (AYA): Evaluation of the Characteristics, Treatment Strategies, and Prognostic Factors in a Monocentric Retrospective Study
por: Del Fiore, Paolo, et al.
Publicado: (2021)

Melanoma of Unknown Primary: Evaluation of the Characteristics, Treatment Strategies, Prognostic Factors in a Monocentric Retrospective Study
por: Del Fiore, Paolo, et al.
Publicado: (2021)

Epstein-Barr virus and telomerase: from cell immortalization to therapy
por: Dolcetti, Riccardo, et al.
Publicado: (2014)

Corrigendum: Melanoma of Unknown Primary: Evaluation of the Characteristics, Treatment Strategies, Prognostic Factors in a Monocentric Retrospective Study
por: Del Fiore, Paolo, et al.
Publicado: (2021)

TERT Extra-Telomeric Roles: Antioxidant Activity and Mitochondrial Protection
por: Marinaccio, Jessica, et al.
Publicado: (2023)

Altitude Effect on Cutaneous Melanoma Epidemiology in the Veneto Region (Northern Italy): A Pilot Study
por: Del Fiore, Paolo, et al.
Publicado: (2022)

TERT promoter mutations in melanoma survival
por: Nagore, Eduardo, et al.
Publicado: (2019)

TERT Promoter Mutations and Telomerase in Melanoma
por: Guo, Yuchen, et al.
Publicado: (2022)

Predictors of toxicity for metastatic melanoma patients treated with ipilimumab
por: Valpione, Sara, et al.
Publicado: (2015)

The MAPK pathway as an apoptosis enhancer in melanoma
por: Haydn, Johannes M., et al.
Publicado: (2014)

TERT promoter mutations and monoallelic activation of TERT in cancer
por: Huang, F W, et al.
Publicado: (2015)

Long-term Survival of Patients With Invasive Ultra-thin Cutaneous Melanoma: A Single-center Retrospective Analysis
por: Vecchiato, Antonella, et al.
Publicado: (2016)

(R)-N-{2-tert-Butyl-2-[(R)-tert-butylsulfonamido]ethylidene}-tert-butanesulfonamide
por: Hu, Yu, et al.
Publicado: (2008)

Immune Activation, Exhaustion and Senescence Profiles as Possible Predictors of Cancer in Liver Transplanted Patients
por: Petrara, Maria Raffaella, et al.
Publicado: (2022)

Melanoma M (Zero): Diagnosis and Therapy
por: Rastrelli, Marco, et al.
Publicado: (2013)

Germline TERT promoter mutations are rare in familial melanoma
por: Harland, Mark, et al.
Publicado: (2015)

Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody
por: Masui, Kenta, et al.
Publicado: (2018)

Exploring the plant-associated bacterial communities in Medicago sativa L
por: Frascella, Arcangela, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tjol2drvqldorvrbja800n9pnf