Cargando…

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat shock protein (HSP) molecular chaperones that pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prince, Thomas L., Lang, Benjamin J., Guerrero-Gimenez, Martin E., Fernandez-Muñoz, Juan Manuel, Ackerman, Andrew, Calderwood, Stuart K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226471/ https://www.ncbi.nlm.nih.gov/pubmed/32331382 http://dx.doi.org/10.3390/cells9041046

Ejemplares similares

Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1
por: Calderwood, Stuart K., et al.
Publicado: (2017)

Protein Kinase A Regulates Molecular Chaperone Transcription and Protein Aggregation
por: Zhang, Yue, et al.
Publicado: (2011)

Regulation of a Novel Splice Variant of Early Growth Response 4 (EGR4-S) by HER+ Signalling and HSF1 in Breast Cancer
por: Drake, Jeremy M., et al.
Publicado: (2022)

Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
por: Lang, Benjamin J., et al.
Publicado: (2019)

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis
por: Chou, Shiuh-Dih, et al.
Publicado: (2012)

MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration
por: Okusha, Yuka, et al.
Publicado: (2022)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
por: Kijima, Toshiki, et al.
Publicado: (2018)

Novel Isoforms of Heat Shock Transcription Factor 1, HSF1γα and HSF1γβ, Regulate Chaperone Protein Gene Transcription
por: Neueder, Andreas, et al.
Publicado: (2014)

Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia
por: Ganguly, Siddhartha, et al.
Publicado: (2015)

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
por: Zheng, Xu, et al.
Publicado: (2016)

The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis
por: Qiao, Aijun, et al.
Publicado: (2017)

Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
por: Wang, Ping, et al.
Publicado: (2017)

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response
por: Katiyar, Arpit, et al.
Publicado: (2020)

HSF1 REGULATION OF β-CATENIN IN MAMMARY CANCER CELLS THROUGH CONTROL OF HUR / ELAVL1 EXPRESSION
por: Chou, Shiuh-Dih, et al.
Publicado: (2014)

HSF1-Controlled and Age-Associated Chaperone Capacity in Neurons and Muscle Cells of C. elegans
por: Kern, Andreas, et al.
Publicado: (2010)

SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock
por: Liebelt, Frauke, et al.
Publicado: (2019)

Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
por: Nishioka, Yuki, et al.
Publicado: (2021)

Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells
por: Etard, Christelle, et al.
Publicado: (2015)

Substance use and common contributors to morbidity: A genetics perspective
por: Sanchez-Roige, Sandra, et al.
Publicado: (2022)

Gas Pressure From the Endoscope: An Unexplored Contributor to Morbidity and Mortality?
por: Wardhan, Richa, et al.
Publicado: (2022)

Synaptic Wnt signaling—a contributor to major psychiatric disorders?
por: Okerlund, Nathan D., et al.
Publicado: (2011)

Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1–mediated heat shock response
por: Miles, Jay, et al.
Publicado: (2023)

Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity
por: Dong, Ying, et al.
Publicado: (2018)

Why Hungarians Have Sex (YSEX?-HSF)
por: Meskó, Norbert, et al.
Publicado: (2021)

Gut Microbiota Is a Major Contributor to Adiposity in Pigs
por: Yang, Hua, et al.
Publicado: (2018)

HSF1 and HSF3 cooperatively regulate the heat shock response in lizards
por: Takii, Ryosuke, et al.
Publicado: (2017)

Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry
por: Simon, Bertrand, et al.
Publicado: (2022)

Mast cells are major contributors to the pathophysiology of Graves’ Ophthalmopathy (GO)
por: Van Steensel, L, et al.
Publicado: (2010)

Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis
por: Sapalidis, Konstantinos, et al.
Publicado: (2019)

Microbial rhodopsins are major contributors to the solar energy captured in the sea
por: Gómez-Consarnau, Laura, et al.
Publicado: (2019)

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies
por: Kauppila, Timo E. S., et al.
Publicado: (2018)

Genetic and constitutional factors are major contributors to substantia nigra hyperechogenicity
por: Vázquez-Costa, Juan F., et al.
Publicado: (2017)

Achieving Value in Spine Surgery: 10 Major Cost Contributors
por: Philipp, Lucas R., et al.
Publicado: (2021)

CYP1B1 copy number variation is not a major contributor to primary congenital glaucoma
por: Souzeau, Emmanuelle, et al.
Publicado: (2015)

Genome-Wide Characterization and Expression of the Hsf Gene Family in Salvia miltiorrhiza (Danshen) and the Potential Thermotolerance of SmHsf1 and SmHsf7 in Yeast
por: Qu, Renjun, et al.
Publicado: (2023)

Is there a role for HSF1 in viral infections?
por: Reyes, Antonia, et al.
Publicado: (2022)

Contributors
Publicado: (2009)

To Contributors
Publicado: (1859)

To Contributors
Publicado: (1871)

To Contributors
Publicado: (1867)

Cannot write session to /tmp/vufind_sessions/sess_g8b1r1pt1b961vuoal90idavdr