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Recent Synthetic Approaches towards Small Molecule Reactivators of p53

The tumor suppressor protein p53 is often called “the genome guardian” and controls the cell cycle and the integrity of DNA, as well as other important cellular functions. Its main function is to trigger the process of apoptosis in tumor cells, and approximately 50% of all cancers are related to the...

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Autores principales: Silva, Jerson L., Lima, Carolina G. S., Rangel, Luciana P., Ferretti, Giulia D. S., Pauli, Fernanda P., Ribeiro, Ruan C. B., da Silva, Thais de B., da Silva, Fernando C., Ferreira, Vitor F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226499/
https://www.ncbi.nlm.nih.gov/pubmed/32326087
http://dx.doi.org/10.3390/biom10040635
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author Silva, Jerson L.
Lima, Carolina G. S.
Rangel, Luciana P.
Ferretti, Giulia D. S.
Pauli, Fernanda P.
Ribeiro, Ruan C. B.
da Silva, Thais de B.
da Silva, Fernando C.
Ferreira, Vitor F.
author_facet Silva, Jerson L.
Lima, Carolina G. S.
Rangel, Luciana P.
Ferretti, Giulia D. S.
Pauli, Fernanda P.
Ribeiro, Ruan C. B.
da Silva, Thais de B.
da Silva, Fernando C.
Ferreira, Vitor F.
author_sort Silva, Jerson L.
collection PubMed
description The tumor suppressor protein p53 is often called “the genome guardian” and controls the cell cycle and the integrity of DNA, as well as other important cellular functions. Its main function is to trigger the process of apoptosis in tumor cells, and approximately 50% of all cancers are related to the inactivation of the p53 protein through mutations in the TP53 gene. Due to the association of mutant p53 with cancer therapy resistance, different forms of restoration of p53 have been subject of intense research in recent years. In this sense, this review focus on the main currently adopted approaches for activation and reactivation of p53 tumor suppressor function, focusing on the synthetic approaches that are involved in the development and preparation of such small molecules.
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spelling pubmed-72264992020-05-18 Recent Synthetic Approaches towards Small Molecule Reactivators of p53 Silva, Jerson L. Lima, Carolina G. S. Rangel, Luciana P. Ferretti, Giulia D. S. Pauli, Fernanda P. Ribeiro, Ruan C. B. da Silva, Thais de B. da Silva, Fernando C. Ferreira, Vitor F. Biomolecules Review The tumor suppressor protein p53 is often called “the genome guardian” and controls the cell cycle and the integrity of DNA, as well as other important cellular functions. Its main function is to trigger the process of apoptosis in tumor cells, and approximately 50% of all cancers are related to the inactivation of the p53 protein through mutations in the TP53 gene. Due to the association of mutant p53 with cancer therapy resistance, different forms of restoration of p53 have been subject of intense research in recent years. In this sense, this review focus on the main currently adopted approaches for activation and reactivation of p53 tumor suppressor function, focusing on the synthetic approaches that are involved in the development and preparation of such small molecules. MDPI 2020-04-20 /pmc/articles/PMC7226499/ /pubmed/32326087 http://dx.doi.org/10.3390/biom10040635 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Silva, Jerson L.
Lima, Carolina G. S.
Rangel, Luciana P.
Ferretti, Giulia D. S.
Pauli, Fernanda P.
Ribeiro, Ruan C. B.
da Silva, Thais de B.
da Silva, Fernando C.
Ferreira, Vitor F.
Recent Synthetic Approaches towards Small Molecule Reactivators of p53
title Recent Synthetic Approaches towards Small Molecule Reactivators of p53
title_full Recent Synthetic Approaches towards Small Molecule Reactivators of p53
title_fullStr Recent Synthetic Approaches towards Small Molecule Reactivators of p53
title_full_unstemmed Recent Synthetic Approaches towards Small Molecule Reactivators of p53
title_short Recent Synthetic Approaches towards Small Molecule Reactivators of p53
title_sort recent synthetic approaches towards small molecule reactivators of p53
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226499/
https://www.ncbi.nlm.nih.gov/pubmed/32326087
http://dx.doi.org/10.3390/biom10040635
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