ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition

Germ cell tumors (GCTs) are the most common solid malignancies found in young men. Although they generally have high cure rates, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In a previous stud...

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Detalles Bibliográficos
Autores principales: Kurz, Lukas, Miklyaeva, Alissa, Skowron, Margaretha A., Overbeck, Nina, Poschmann, Gereon, Becker, Teresa, Eul, Katharina, Kurz, Thomas, Schönberger, Stefan, Calaminus, Gabriele, Stühler, Kai, Dykhuizen, Emily, Albers, Peter, Nettersheim, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226530/
https://www.ncbi.nlm.nih.gov/pubmed/32272809
http://dx.doi.org/10.3390/cancers12040905

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