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Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort
Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a low-incidence country. GBC patients diagnosed between 2005 and 2016 with GBC wer...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226578/ https://www.ncbi.nlm.nih.gov/pubmed/32283627 http://dx.doi.org/10.3390/cancers12040918 |
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author | de Savornin Lohman, Elise de Bitter, Tessa Verhoeven, Rob van der Geest, Lydia Hagendoorn, Jeroen Haj Mohammad, Nadia Daams, Freek Klümpen, Heinz-Josef van Gulik, Thomas Erdmann, Joris de Boer, Marieke Hoogwater, Frederik Koerkamp, Bas Groot Braat, Andries Verheij, Joanne Nagtegaal, Iris van Laarhoven, Cornelis van den Boezem, Peter van der Post, Rachel de Reuver, Philip |
author_facet | de Savornin Lohman, Elise de Bitter, Tessa Verhoeven, Rob van der Geest, Lydia Hagendoorn, Jeroen Haj Mohammad, Nadia Daams, Freek Klümpen, Heinz-Josef van Gulik, Thomas Erdmann, Joris de Boer, Marieke Hoogwater, Frederik Koerkamp, Bas Groot Braat, Andries Verheij, Joanne Nagtegaal, Iris van Laarhoven, Cornelis van den Boezem, Peter van der Post, Rachel de Reuver, Philip |
author_sort | de Savornin Lohman, Elise |
collection | PubMed |
description | Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a low-incidence country. GBC patients diagnosed between 2005 and 2016 with GBC were identified from the Netherlands Cancer Registry. Patients were grouped according to time period (2005–2009/2010–2016) and disease stage. Trends in treatment and overall survival (OS) were analyzed. In total 1834 patients were included: 661 (36%) patients with resected, 278 (15%) with non-resected non-metastatic, and 895 (49%) with metastatic GBC. Use of radical versus simple cholecystectomy (12% vs. 26%, p < 0.001) in early (pT1b/T2) GBC increased. More patients with metastatic GBC received chemotherapy (11% vs. 29%, p < 0.001). OS improved from 4.8 months (2005–2009) to 6.1 months (2010–2016) (p = 0.012). Median OS increased over time (2005–2009 vs. 2010–2016) in resected (19.4 to 26.8 months, p = 0.038) and metastatic (2.3 vs. 3.4 months, p = 0.001) GBC but not in unresected, non-metastatic GBC. In early GBC, patients with radical cholecystectomy had a median OS of 76.7 compared to 18.4 months for simple cholecystectomy (p < 0.001). Palliative chemotherapy showed superior (p < 0.001) survival in metastatic (7.3 versus 2.1 months) and non-resected non-metastatic (7.7 versus 3.5 months) GBC. In conclusion, survival of GBC remains poor. Radical surgery and palliative chemotherapy appear to improve prognosis but remain under-utilized. |
format | Online Article Text |
id | pubmed-7226578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72265782020-05-18 Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort de Savornin Lohman, Elise de Bitter, Tessa Verhoeven, Rob van der Geest, Lydia Hagendoorn, Jeroen Haj Mohammad, Nadia Daams, Freek Klümpen, Heinz-Josef van Gulik, Thomas Erdmann, Joris de Boer, Marieke Hoogwater, Frederik Koerkamp, Bas Groot Braat, Andries Verheij, Joanne Nagtegaal, Iris van Laarhoven, Cornelis van den Boezem, Peter van der Post, Rachel de Reuver, Philip Cancers (Basel) Article Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a low-incidence country. GBC patients diagnosed between 2005 and 2016 with GBC were identified from the Netherlands Cancer Registry. Patients were grouped according to time period (2005–2009/2010–2016) and disease stage. Trends in treatment and overall survival (OS) were analyzed. In total 1834 patients were included: 661 (36%) patients with resected, 278 (15%) with non-resected non-metastatic, and 895 (49%) with metastatic GBC. Use of radical versus simple cholecystectomy (12% vs. 26%, p < 0.001) in early (pT1b/T2) GBC increased. More patients with metastatic GBC received chemotherapy (11% vs. 29%, p < 0.001). OS improved from 4.8 months (2005–2009) to 6.1 months (2010–2016) (p = 0.012). Median OS increased over time (2005–2009 vs. 2010–2016) in resected (19.4 to 26.8 months, p = 0.038) and metastatic (2.3 vs. 3.4 months, p = 0.001) GBC but not in unresected, non-metastatic GBC. In early GBC, patients with radical cholecystectomy had a median OS of 76.7 compared to 18.4 months for simple cholecystectomy (p < 0.001). Palliative chemotherapy showed superior (p < 0.001) survival in metastatic (7.3 versus 2.1 months) and non-resected non-metastatic (7.7 versus 3.5 months) GBC. In conclusion, survival of GBC remains poor. Radical surgery and palliative chemotherapy appear to improve prognosis but remain under-utilized. MDPI 2020-04-09 /pmc/articles/PMC7226578/ /pubmed/32283627 http://dx.doi.org/10.3390/cancers12040918 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Savornin Lohman, Elise de Bitter, Tessa Verhoeven, Rob van der Geest, Lydia Hagendoorn, Jeroen Haj Mohammad, Nadia Daams, Freek Klümpen, Heinz-Josef van Gulik, Thomas Erdmann, Joris de Boer, Marieke Hoogwater, Frederik Koerkamp, Bas Groot Braat, Andries Verheij, Joanne Nagtegaal, Iris van Laarhoven, Cornelis van den Boezem, Peter van der Post, Rachel de Reuver, Philip Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort |
title | Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort |
title_full | Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort |
title_fullStr | Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort |
title_full_unstemmed | Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort |
title_short | Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort |
title_sort | trends in treatment and survival of gallbladder cancer in the netherlands; identifying gaps and opportunities from a nation-wide cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226578/ https://www.ncbi.nlm.nih.gov/pubmed/32283627 http://dx.doi.org/10.3390/cancers12040918 |
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