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Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer

Background: The purpose of this study was to evaluate the clinical outcomes following postoperative chemotherapy (XP) versus chemoradiotherapy (XP-RT) according to mesenchymal subtype based on RNA sequencing in gastric cancer (GC) in a cohort of the Adjuvant chemoRadioTherapy In Stomach Tumor (ARTIS...

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Autores principales: Yu, Jeong Il, Park, Hee Chul, Lee, Jeeyun, Choi, Changhoon, Kang, Won Ki, Park, Se Hoon, Kim, Seung Tae, Sohn, Tae Sung, Lee, Jun Ho, An, Ji Yeong, Choi, Min Gew, Bae, Jae Moon, Kim, Kyoung-Mee, Han, Heewon, Kim, Kyunga, Kim, Sung, Lim, Do Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226608/
https://www.ncbi.nlm.nih.gov/pubmed/32290335
http://dx.doi.org/10.3390/cancers12040943
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author Yu, Jeong Il
Park, Hee Chul
Lee, Jeeyun
Choi, Changhoon
Kang, Won Ki
Park, Se Hoon
Kim, Seung Tae
Sohn, Tae Sung
Lee, Jun Ho
An, Ji Yeong
Choi, Min Gew
Bae, Jae Moon
Kim, Kyoung-Mee
Han, Heewon
Kim, Kyunga
Kim, Sung
Lim, Do Hoon
author_facet Yu, Jeong Il
Park, Hee Chul
Lee, Jeeyun
Choi, Changhoon
Kang, Won Ki
Park, Se Hoon
Kim, Seung Tae
Sohn, Tae Sung
Lee, Jun Ho
An, Ji Yeong
Choi, Min Gew
Bae, Jae Moon
Kim, Kyoung-Mee
Han, Heewon
Kim, Kyunga
Kim, Sung
Lim, Do Hoon
author_sort Yu, Jeong Il
collection PubMed
description Background: The purpose of this study was to evaluate the clinical outcomes following postoperative chemotherapy (XP) versus chemoradiotherapy (XP-RT) according to mesenchymal subtype based on RNA sequencing in gastric cancer (GC) in a cohort of the Adjuvant chemoRadioTherapy In Stomach Tumor (ARTIST) trial. Methods: Of the 458 patients enrolled in the ARTIST trial, formalin-fixed, paraffin-embedded (FFPE) specimens were available from 106 (23.1%) patients for RNA analysis. The mesenchymal subtype was classified according to a previously reported 71-gene MSS/EMT signature using the NanoString assay. Results: Of the 106 patients analyzed (50 in XP arm, 56 in XP-RT arm), 36 (34.0%) patients were categorized as mesenchymal subtype by NanoString assay. Recurrence-free survival (RFS, p = 0.009, hazard ratio (HR) = 2.11, 95% confidence interval (CI): 1.21–3.70) and overall survival (OS, p = 0.003, HR = 2.28, 95% CI: 1.31–3.96) were significantly lower in the mesenchymal subtype than in the non-mesenchymal subtype. In terms of post-operative radiotherapy (RT), mesenchymal subtype was not an independent variable to predict RFS or OS regardless to the assigned arm (XP with or without RT) in this patient cohort. However, there was a trend in the adjuvant XP arm, which showed higher OS than the XP-RT arm for the mesenchymal subtype and lower OS than the XP-RT arm for the non-mesenchymal subtype. Conclusions: We could not determine any significant differences between the mesenchymal and non-mesenchymal subtypes with respect to the effects of adjuvant XP with or without RT in gastric cancer following curative surgery.
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spelling pubmed-72266082020-05-18 Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer Yu, Jeong Il Park, Hee Chul Lee, Jeeyun Choi, Changhoon Kang, Won Ki Park, Se Hoon Kim, Seung Tae Sohn, Tae Sung Lee, Jun Ho An, Ji Yeong Choi, Min Gew Bae, Jae Moon Kim, Kyoung-Mee Han, Heewon Kim, Kyunga Kim, Sung Lim, Do Hoon Cancers (Basel) Article Background: The purpose of this study was to evaluate the clinical outcomes following postoperative chemotherapy (XP) versus chemoradiotherapy (XP-RT) according to mesenchymal subtype based on RNA sequencing in gastric cancer (GC) in a cohort of the Adjuvant chemoRadioTherapy In Stomach Tumor (ARTIST) trial. Methods: Of the 458 patients enrolled in the ARTIST trial, formalin-fixed, paraffin-embedded (FFPE) specimens were available from 106 (23.1%) patients for RNA analysis. The mesenchymal subtype was classified according to a previously reported 71-gene MSS/EMT signature using the NanoString assay. Results: Of the 106 patients analyzed (50 in XP arm, 56 in XP-RT arm), 36 (34.0%) patients were categorized as mesenchymal subtype by NanoString assay. Recurrence-free survival (RFS, p = 0.009, hazard ratio (HR) = 2.11, 95% confidence interval (CI): 1.21–3.70) and overall survival (OS, p = 0.003, HR = 2.28, 95% CI: 1.31–3.96) were significantly lower in the mesenchymal subtype than in the non-mesenchymal subtype. In terms of post-operative radiotherapy (RT), mesenchymal subtype was not an independent variable to predict RFS or OS regardless to the assigned arm (XP with or without RT) in this patient cohort. However, there was a trend in the adjuvant XP arm, which showed higher OS than the XP-RT arm for the mesenchymal subtype and lower OS than the XP-RT arm for the non-mesenchymal subtype. Conclusions: We could not determine any significant differences between the mesenchymal and non-mesenchymal subtypes with respect to the effects of adjuvant XP with or without RT in gastric cancer following curative surgery. MDPI 2020-04-10 /pmc/articles/PMC7226608/ /pubmed/32290335 http://dx.doi.org/10.3390/cancers12040943 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Jeong Il
Park, Hee Chul
Lee, Jeeyun
Choi, Changhoon
Kang, Won Ki
Park, Se Hoon
Kim, Seung Tae
Sohn, Tae Sung
Lee, Jun Ho
An, Ji Yeong
Choi, Min Gew
Bae, Jae Moon
Kim, Kyoung-Mee
Han, Heewon
Kim, Kyunga
Kim, Sung
Lim, Do Hoon
Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
title Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
title_full Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
title_fullStr Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
title_full_unstemmed Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
title_short Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
title_sort outcomes of radiotherapy for mesenchymal and non-mesenchymal subtypes of gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226608/
https://www.ncbi.nlm.nih.gov/pubmed/32290335
http://dx.doi.org/10.3390/cancers12040943
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