Cargando…

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma

Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, SF3B1 and EIF1AX, most being linked to metastatic-risk. To gain further insight into the molecular landscape of UM, we design...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thornton, Sophie, Coupland, Sarah E., Olohan, Lisa, Sibbring, Julie S., Kenny, John G., Hertz-Fowler, Christiane, Liu, Xuan, Haldenby, Sam, Heimann, Heinrich, Hussain, Rumana, Kipling, Natalie, Taktak, Azzam, Kalirai, Helen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226611/ https://www.ncbi.nlm.nih.gov/pubmed/32340176 http://dx.doi.org/10.3390/cancers12041039

Ejemplares similares

Small High-Risk Uveal Melanomas Have a Lower Mortality Rate
por: Hussain, Rumana N., et al.
Publicado: (2021)

A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional “Liverpool Ocular Oncology Centre”, UK
por: Rola, Alda Cunha, et al.
Publicado: (2022)

Parsimonious Models for Predicting Mortality from Choroidal Melanoma
por: Damato, Bertil, et al.
Publicado: (2020)

Sensitivity and Specificity of Different Prognostic Systems in Guiding Surveillance for Metastases in Uveal Melanoma
por: Robinson, Helena, et al.
Publicado: (2023)

Vascular Lakes in Uveal Melanoma and Their Association With Outcome
por: Jones, Hayley, et al.
Publicado: (2022)

Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma
por: Farquhar, Neil, et al.
Publicado: (2017)

Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons
por: Hussain, Rumana N., et al.
Publicado: (2020)

Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma
por: Caines, Rhydian, et al.
Publicado: (2015)

Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing
por: Kalirai, H, et al.
Publicado: (2014)

Is accurate routine cancer prognostication psychologically harmful? 5-year outcomes of life expectancy prognostication in uveal melanoma survivors
por: Brown, Stephen L., et al.
Publicado: (2021)

Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention
por: Sabat‐Pośpiech, Dorota, et al.
Publicado: (2022)

Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma
por: Krishna, Yamini, et al.
Publicado: (2020)

MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators
por: Aughton, Karen, et al.
Publicado: (2020)

Investigating the Role of DUSP4 in Uveal Melanoma
por: Aughton, Karen, et al.
Publicado: (2022)

Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study
por: Cunha Rola, Alda, et al.
Publicado: (2020)

Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture
por: Aughton, Karen, et al.
Publicado: (2020)

In-depth proteomic profiling of the uveal melanoma secretome
por: Angi, Martina, et al.
Publicado: (2016)

Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers
por: Jang, Geeng-Fu, et al.
Publicado: (2021)

Piloting a Deep Learning Model for Predicting Nuclear BAP1 Immunohistochemical Expression of Uveal Melanoma from Hematoxylin-and-Eosin Sections
por: Zhang, Hongrun, et al.
Publicado: (2020)

Prediction of all-cause mortality from 24 month trajectories in patient-reported psychological, clinical and quality of life outcomes in uveal melanoma patients
por: Brown, Stephen L., et al.
Publicado: (2021)

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development
por: Figueiredo, Carlos R, et al.
Publicado: (2020)

‘I Don't Like Uncertainty, I Like to Know’: How and why uveal melanoma patients consent to life expectancy prognostication
por: Brown, Stephen L., et al.
Publicado: (2022)

Optic nerve head sarcoidosis mimicking an intraocular tumour, and occurring as the first manifestation of neuro-ocular sarcoidosis
por: Krishna, Yamini, et al.
Publicado: (2020)

Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery
por: Yin, Jie, et al.
Publicado: (2023)

Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome
por: Kenawy, Nihal, et al.
Publicado: (2019)

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
por: Groenewoud, Arwin, et al.
Publicado: (2023)

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells
por: Slater, Kayleigh, et al.
Publicado: (2020)

Diagnostic imaging of retinal astrocytomas: A case-series
por: McLean, Keri, et al.
Publicado: (2022)

Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin’s lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins
por: Middle, Stephen, et al.
Publicado: (2015)

Applying Single-Cell Technology in Uveal Melanomas: Current Trends and Perspectives for Improving Uveal Melanoma Metastasis Surveillance and Tumor Profiling
por: Wang, Mona Meng, et al.
Publicado: (2021)

Formation of $^{117}In-H$ pairs after annealing of GaN implanted with $^{117}Cd(^{117}In)$
por: Dietrich, M, et al.
Publicado: (2001)

Decay study of the $^{117}$Cs and $^{117}$Xe nuclei
por: Marguier, G, et al.
Publicado: (1985)

A Further Protest against the Routine Use of Purgatives
Publicado: (1912)

The 117 call alert system in Sierra Leone: from rapid Ebola notification to routine death reporting
por: Alpren, Charles, et al.
Publicado: (2017)

Regressing Conjunctival Nevus in a Child
por: Ho, Vivian Wing-Man, et al.
Publicado: (2018)

Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines
por: Dithmer, Michaela, et al.
Publicado: (2017)

Uveal Melanoma
por: Papastefanou, Vasilios P., et al.
Publicado: (2011)

Uveal Melanoma
por: Pfeffer, Ulrich
Publicado: (2019)

Gamma knife radiosurgery for the treatment of uveal melanoma and uveal metastases
por: Reynolds, Margaret M., et al.
Publicado: (2017)

Assessment of Different Circulating Tumor Cell Platforms for Uveal Melanoma: Potential Impact for Future Routine Clinical Practice
por: Martel, Arnaud, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_svcogqn76rhkt6j8k09edn6mj4