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Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience

In recent years, the genomics community has witnessed the growth of large research biobanks, which collect DNA samples for research purposes. Depending on how and where the samples are genotyped, biobanks also offer the potential opportunity to return actionable genomic results to the clinical setti...

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Autores principales: Aquilante, Christina L, Kao, David P, Trinkley, Katy E, Lin, Chen-Tan, Crooks, Kristy R, Hearst, Emily C, Hess, Steven J, Kudron, Elizabeth L, Lee, Yee Ming, Liko, Ina, Lowery, Jan, Mathias, Rasika A, Monte, Andrew A, Rafaels, Nicholas, Rioth, Matthew J, Roberts, Emily R, Taylor, Matthew RG, Williamson, Connie, Barnes, Kathleen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226704/
https://www.ncbi.nlm.nih.gov/pubmed/32077359
http://dx.doi.org/10.2217/pgs-2020-0007
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author Aquilante, Christina L
Kao, David P
Trinkley, Katy E
Lin, Chen-Tan
Crooks, Kristy R
Hearst, Emily C
Hess, Steven J
Kudron, Elizabeth L
Lee, Yee Ming
Liko, Ina
Lowery, Jan
Mathias, Rasika A
Monte, Andrew A
Rafaels, Nicholas
Rioth, Matthew J
Roberts, Emily R
Taylor, Matthew RG
Williamson, Connie
Barnes, Kathleen C
author_facet Aquilante, Christina L
Kao, David P
Trinkley, Katy E
Lin, Chen-Tan
Crooks, Kristy R
Hearst, Emily C
Hess, Steven J
Kudron, Elizabeth L
Lee, Yee Ming
Liko, Ina
Lowery, Jan
Mathias, Rasika A
Monte, Andrew A
Rafaels, Nicholas
Rioth, Matthew J
Roberts, Emily R
Taylor, Matthew RG
Williamson, Connie
Barnes, Kathleen C
author_sort Aquilante, Christina L
collection PubMed
description In recent years, the genomics community has witnessed the growth of large research biobanks, which collect DNA samples for research purposes. Depending on how and where the samples are genotyped, biobanks also offer the potential opportunity to return actionable genomic results to the clinical setting. We developed a preemptive clinical pharmacogenomic implementation initiative via a health system-wide research biobank at the University of Colorado. Here, we describe how preemptive return of clinical pharmacogenomic results via a research biobank is feasible, particularly when coupled with strong institutional support to maximize the impact and efficiency of biobank resources, a multidisciplinary implementation team, automated clinical decision support tools, and proactive strategies to engage stakeholders early in the clinical decision support tool development process.
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spelling pubmed-72267042020-05-18 Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience Aquilante, Christina L Kao, David P Trinkley, Katy E Lin, Chen-Tan Crooks, Kristy R Hearst, Emily C Hess, Steven J Kudron, Elizabeth L Lee, Yee Ming Liko, Ina Lowery, Jan Mathias, Rasika A Monte, Andrew A Rafaels, Nicholas Rioth, Matthew J Roberts, Emily R Taylor, Matthew RG Williamson, Connie Barnes, Kathleen C Pharmacogenomics Institutional Profile In recent years, the genomics community has witnessed the growth of large research biobanks, which collect DNA samples for research purposes. Depending on how and where the samples are genotyped, biobanks also offer the potential opportunity to return actionable genomic results to the clinical setting. We developed a preemptive clinical pharmacogenomic implementation initiative via a health system-wide research biobank at the University of Colorado. Here, we describe how preemptive return of clinical pharmacogenomic results via a research biobank is feasible, particularly when coupled with strong institutional support to maximize the impact and efficiency of biobank resources, a multidisciplinary implementation team, automated clinical decision support tools, and proactive strategies to engage stakeholders early in the clinical decision support tool development process. Future Medicine Ltd 2020-02-20 2020-02 /pmc/articles/PMC7226704/ /pubmed/32077359 http://dx.doi.org/10.2217/pgs-2020-0007 Text en © 2020 Christina Aquilante This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Institutional Profile
Aquilante, Christina L
Kao, David P
Trinkley, Katy E
Lin, Chen-Tan
Crooks, Kristy R
Hearst, Emily C
Hess, Steven J
Kudron, Elizabeth L
Lee, Yee Ming
Liko, Ina
Lowery, Jan
Mathias, Rasika A
Monte, Andrew A
Rafaels, Nicholas
Rioth, Matthew J
Roberts, Emily R
Taylor, Matthew RG
Williamson, Connie
Barnes, Kathleen C
Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience
title Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience
title_full Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience
title_fullStr Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience
title_full_unstemmed Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience
title_short Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience
title_sort clinical implementation of pharmacogenomics via a health system-wide research biobank: the university of colorado experience
topic Institutional Profile
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226704/
https://www.ncbi.nlm.nih.gov/pubmed/32077359
http://dx.doi.org/10.2217/pgs-2020-0007
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