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Role and Mechanisms of Mitophagy in Liver Diseases
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226762/ https://www.ncbi.nlm.nih.gov/pubmed/32244304 http://dx.doi.org/10.3390/cells9040837 |
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author | Ma, Xiaowen McKeen, Tara Zhang, Jianhua Ding, Wen-Xing |
author_facet | Ma, Xiaowen McKeen, Tara Zhang, Jianhua Ding, Wen-Xing |
author_sort | Ma, Xiaowen |
collection | PubMed |
description | The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver’s physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases. |
format | Online Article Text |
id | pubmed-7226762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72267622020-05-18 Role and Mechanisms of Mitophagy in Liver Diseases Ma, Xiaowen McKeen, Tara Zhang, Jianhua Ding, Wen-Xing Cells Review The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver’s physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases. MDPI 2020-03-31 /pmc/articles/PMC7226762/ /pubmed/32244304 http://dx.doi.org/10.3390/cells9040837 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ma, Xiaowen McKeen, Tara Zhang, Jianhua Ding, Wen-Xing Role and Mechanisms of Mitophagy in Liver Diseases |
title | Role and Mechanisms of Mitophagy in Liver Diseases |
title_full | Role and Mechanisms of Mitophagy in Liver Diseases |
title_fullStr | Role and Mechanisms of Mitophagy in Liver Diseases |
title_full_unstemmed | Role and Mechanisms of Mitophagy in Liver Diseases |
title_short | Role and Mechanisms of Mitophagy in Liver Diseases |
title_sort | role and mechanisms of mitophagy in liver diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226762/ https://www.ncbi.nlm.nih.gov/pubmed/32244304 http://dx.doi.org/10.3390/cells9040837 |
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