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Role and Mechanisms of Mitophagy in Liver Diseases

The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy...

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Detalles Bibliográficos
Autores principales: Ma, Xiaowen, McKeen, Tara, Zhang, Jianhua, Ding, Wen-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226762/
https://www.ncbi.nlm.nih.gov/pubmed/32244304
http://dx.doi.org/10.3390/cells9040837
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author Ma, Xiaowen
McKeen, Tara
Zhang, Jianhua
Ding, Wen-Xing
author_facet Ma, Xiaowen
McKeen, Tara
Zhang, Jianhua
Ding, Wen-Xing
author_sort Ma, Xiaowen
collection PubMed
description The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver’s physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases.
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spelling pubmed-72267622020-05-18 Role and Mechanisms of Mitophagy in Liver Diseases Ma, Xiaowen McKeen, Tara Zhang, Jianhua Ding, Wen-Xing Cells Review The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver’s physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases. MDPI 2020-03-31 /pmc/articles/PMC7226762/ /pubmed/32244304 http://dx.doi.org/10.3390/cells9040837 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Xiaowen
McKeen, Tara
Zhang, Jianhua
Ding, Wen-Xing
Role and Mechanisms of Mitophagy in Liver Diseases
title Role and Mechanisms of Mitophagy in Liver Diseases
title_full Role and Mechanisms of Mitophagy in Liver Diseases
title_fullStr Role and Mechanisms of Mitophagy in Liver Diseases
title_full_unstemmed Role and Mechanisms of Mitophagy in Liver Diseases
title_short Role and Mechanisms of Mitophagy in Liver Diseases
title_sort role and mechanisms of mitophagy in liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226762/
https://www.ncbi.nlm.nih.gov/pubmed/32244304
http://dx.doi.org/10.3390/cells9040837
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