Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an adaptor protein for the cullin 4A Really Interesting New Gene (RING) E3 ubiquitin ligase (CRL4) complex and functio...

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Autores principales: Minor, Marissa M., Hollinger, F. Blaine, McNees, Adrienne L., Jung, Sung Yun, Jain, Antrix, Hyser, Joseph M., Bissig, Karl-Dimiter, Slagle, Betty L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226812/
https://www.ncbi.nlm.nih.gov/pubmed/32235678
http://dx.doi.org/10.3390/cells9040834

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