The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of J...

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Detalles Bibliográficos
Autores principales: Hammouda, Manel B., Ford, Amy E., Liu, Yuan, Zhang, Jennifer Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226813/
https://www.ncbi.nlm.nih.gov/pubmed/32252279
http://dx.doi.org/10.3390/cells9040857
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author Hammouda, Manel B.
Ford, Amy E.
Liu, Yuan
Zhang, Jennifer Y.
author_facet Hammouda, Manel B.
Ford, Amy E.
Liu, Yuan
Zhang, Jennifer Y.
author_sort Hammouda, Manel B.
collection PubMed
description The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
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spelling pubmed-72268132020-05-18 The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer † Hammouda, Manel B. Ford, Amy E. Liu, Yuan Zhang, Jennifer Y. Cells Review The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. MDPI 2020-04-02 /pmc/articles/PMC7226813/ /pubmed/32252279 http://dx.doi.org/10.3390/cells9040857 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hammouda, Manel B.
Ford, Amy E.
Liu, Yuan
Zhang, Jennifer Y.
The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †
title The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †
title_full The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †
title_fullStr The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †
title_full_unstemmed The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †
title_short The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer †
title_sort jnk signaling pathway in inflammatory skin disorders and cancer †
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226813/
https://www.ncbi.nlm.nih.gov/pubmed/32252279
http://dx.doi.org/10.3390/cells9040857
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