Cargando…

GSK3: A Kinase Balancing Promotion and Resolution of Inflammation

GSK3 has been implicated for years in the regulation of inflammation and addressed in a plethora of scientific reports using a variety of experimental (disease) models and approaches. However, the specific role of GSK3 in the inflammatory process is still not fully understood and controversially dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoffmeister, Leonie, Diekmann, Mareike, Brand, Korbinian, Huber, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226814/
https://www.ncbi.nlm.nih.gov/pubmed/32231133
http://dx.doi.org/10.3390/cells9040820
_version_ 1783534368323534848
author Hoffmeister, Leonie
Diekmann, Mareike
Brand, Korbinian
Huber, René
author_facet Hoffmeister, Leonie
Diekmann, Mareike
Brand, Korbinian
Huber, René
author_sort Hoffmeister, Leonie
collection PubMed
description GSK3 has been implicated for years in the regulation of inflammation and addressed in a plethora of scientific reports using a variety of experimental (disease) models and approaches. However, the specific role of GSK3 in the inflammatory process is still not fully understood and controversially discussed. Following a detailed overview of structure, function, and various regulatory levels, this review focusses on the immunoregulatory functions of GSK3, including the current knowledge obtained from animal models. Its impact on pro-inflammatory cytokine/chemokine profiles, bacterial/viral infections, and the modulation of associated pro-inflammatory transcriptional and signaling pathways is discussed. Moreover, GSK3 contributes to the resolution of inflammation on multiple levels, e.g., via the regulation of pro-resolving mediators, the clearance of apoptotic immune cells, and tissue repair processes. The influence of GSK3 on the development of different forms of stimulation tolerance is also addressed. Collectively, the role of GSK3 as a kinase balancing the initiation/perpetuation and the amelioration/resolution of inflammation is highlighted.
format Online
Article
Text
id pubmed-7226814
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72268142020-05-18 GSK3: A Kinase Balancing Promotion and Resolution of Inflammation Hoffmeister, Leonie Diekmann, Mareike Brand, Korbinian Huber, René Cells Review GSK3 has been implicated for years in the regulation of inflammation and addressed in a plethora of scientific reports using a variety of experimental (disease) models and approaches. However, the specific role of GSK3 in the inflammatory process is still not fully understood and controversially discussed. Following a detailed overview of structure, function, and various regulatory levels, this review focusses on the immunoregulatory functions of GSK3, including the current knowledge obtained from animal models. Its impact on pro-inflammatory cytokine/chemokine profiles, bacterial/viral infections, and the modulation of associated pro-inflammatory transcriptional and signaling pathways is discussed. Moreover, GSK3 contributes to the resolution of inflammation on multiple levels, e.g., via the regulation of pro-resolving mediators, the clearance of apoptotic immune cells, and tissue repair processes. The influence of GSK3 on the development of different forms of stimulation tolerance is also addressed. Collectively, the role of GSK3 as a kinase balancing the initiation/perpetuation and the amelioration/resolution of inflammation is highlighted. MDPI 2020-03-28 /pmc/articles/PMC7226814/ /pubmed/32231133 http://dx.doi.org/10.3390/cells9040820 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hoffmeister, Leonie
Diekmann, Mareike
Brand, Korbinian
Huber, René
GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
title GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
title_full GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
title_fullStr GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
title_full_unstemmed GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
title_short GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
title_sort gsk3: a kinase balancing promotion and resolution of inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226814/
https://www.ncbi.nlm.nih.gov/pubmed/32231133
http://dx.doi.org/10.3390/cells9040820
work_keys_str_mv AT hoffmeisterleonie gsk3akinasebalancingpromotionandresolutionofinflammation
AT diekmannmareike gsk3akinasebalancingpromotionandresolutionofinflammation
AT brandkorbinian gsk3akinasebalancingpromotionandresolutionofinflammation
AT huberrene gsk3akinasebalancingpromotionandresolutionofinflammation