Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ven...

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Autores principales: Bari, Elia, Ferrarotti, Ilaria, Saracino, Laura, Perteghella, Sara, Torre, Maria Luisa, Corsico, Angelo Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226831/
https://www.ncbi.nlm.nih.gov/pubmed/32283815
http://dx.doi.org/10.3390/cells9040924
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author Bari, Elia
Ferrarotti, Ilaria
Saracino, Laura
Perteghella, Sara
Torre, Maria Luisa
Corsico, Angelo Guido
author_facet Bari, Elia
Ferrarotti, Ilaria
Saracino, Laura
Perteghella, Sara
Torre, Maria Luisa
Corsico, Angelo Guido
author_sort Bari, Elia
collection PubMed
description From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ventilation. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. In our opinion, mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 pneumonia, due to the broad pharmacological effects it shows, including anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties.
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spelling pubmed-72268312020-05-18 Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use Bari, Elia Ferrarotti, Ilaria Saracino, Laura Perteghella, Sara Torre, Maria Luisa Corsico, Angelo Guido Cells Perspective From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ventilation. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. In our opinion, mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 pneumonia, due to the broad pharmacological effects it shows, including anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties. MDPI 2020-04-09 /pmc/articles/PMC7226831/ /pubmed/32283815 http://dx.doi.org/10.3390/cells9040924 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Bari, Elia
Ferrarotti, Ilaria
Saracino, Laura
Perteghella, Sara
Torre, Maria Luisa
Corsico, Angelo Guido
Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
title Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
title_full Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
title_fullStr Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
title_full_unstemmed Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
title_short Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
title_sort mesenchymal stromal cell secretome for severe covid-19 infections: premises for the therapeutic use
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226831/
https://www.ncbi.nlm.nih.gov/pubmed/32283815
http://dx.doi.org/10.3390/cells9040924
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