Cargando…
Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer
The role and therapeutic promise of poly-ADP ribose polymerase (PARP) inhibitors in anticancer chemotherapy are increasingly being explored, particularly in adjuvant or maintenance therapy, considering their low efficacy as monotherapy agents and their potentiating effects on concurrently administer...
Autores principales: | Lai, Shiue-Wei, Bamodu, Oluwaseun Adebayo, Chen, Jia-Hong, Wu, Alexander TH, Lee, Wei-Hwa, Chao, Tsu-Yi, Yeh, Chi-Tai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226837/ https://www.ncbi.nlm.nih.gov/pubmed/32276472 http://dx.doi.org/10.3390/cells9040911 |
Ejemplares similares
-
Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition
por: Srinivasan, Gayathri, et al.
Publicado: (2017) -
Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p
por: Lai, Shiue-Wei, et al.
Publicado: (2021) -
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448
por: Bamodu, Oluwaseun Adebayo, et al.
Publicado: (2016) -
Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators
por: McLellan, Jessica L., et al.
Publicado: (2012) -
Targeting the Epigenetic Non-Coding RNA MALAT1/Wnt Signaling Axis as a Therapeutic Approach to Suppress Stemness and Metastasis in Hepatocellular Carcinoma
por: Chang, Hang-Lung, et al.
Publicado: (2020)