NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-β-Lactamase-1 and on the Binding with Flavonols as Inhibitors

[Image: see text] New Delhi metallo-β-lactamase-1 (NDM-1) has recently emerged as a global threat because of its ability to confer resistance to all common β-lactam antibiotics. Understanding the molecular basis of β-lactam hydrolysis by NDM is crucial for designing NDM inhibitors or β-lactams resis...

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Detalles Bibliográficos
Autores principales: Rivière, Gwladys, Oueslati, Saoussen, Gayral, Maud, Créchet, Jean-Bernard, Nhiri, Naïma, Jacquet, Eric, Cintrat, Jean-Christophe, Giraud, François, van Heijenoort, Carine, Lescop, Ewen, Pethe, Stéphanie, Iorga, Bogdan I., Naas, Thierry, Guittet, Eric, Morellet, Nelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226869/
https://www.ncbi.nlm.nih.gov/pubmed/32426604
http://dx.doi.org/10.1021/acsomega.0c00590

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