Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage

Core regulatory transcription factors (CR TFs) establish enhancers with logical ordering during embryogenesis and development. Here we report that in fusion-positive rhabdomyosarcoma, a cancer of the muscle lineage, the chief oncogene PAX3-FOXO1 is driven by a translocated FOXO1 super enhancer (SE)...

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Detalles Bibliográficos
Autores principales: Gryder, Berkley E., Wachtel, Marco, Chang, Kenneth, El Demerdash, Osama, Aboreden, Nicholas G., Mohammed, Wardah, Ewert, Winston, Pomella, Silvia, Rota, Rossella, Wei, Jun S., Song, Young, Stanton, Benjamin Z., Schäfer, Beat, Vakoc, Christopher R., Khan, Javed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226896/
https://www.ncbi.nlm.nih.gov/pubmed/32416589
http://dx.doi.org/10.1016/j.isci.2020.101103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226896/
https://www.ncbi.nlm.nih.gov/pubmed/32416589
http://dx.doi.org/10.1016/j.isci.2020.101103

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