Cargando…

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature

Mitochondrial dysfunction and systemic inflammation are major factors in the development of sarcopenia, but the molecular determinants linking the two mechanisms are only partially understood. The study of extracellular vesicle (EV) trafficking may provide insights into this relationship. Circulatin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Picca, Anna, Beli, Raffaella, Calvani, Riccardo, Coelho-Júnior, Hélio José, Landi, Francesco, Bernabei, Roberto, Bucci, Cecilia, Guerra, Flora, Marzetti, Emanuele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227017/ https://www.ncbi.nlm.nih.gov/pubmed/32326435 http://dx.doi.org/10.3390/cells9040973

Ejemplares similares

Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place?
por: Picca, Anna, et al.
Publicado: (2020)

Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
por: Picca, Anna, et al.
Publicado: (2020)

Circulating Mitochondrial-Derived Vesicles, Inflammatory Biomarkers and Amino Acids in Older Adults With Physical Frailty and Sarcopenia: A Preliminary BIOSPHERE Multi-Marker Study Using Sequential and Orthogonalized Covariance Selection – Linear Discriminant Analysis
por: Marzetti, Emanuele, et al.
Publicado: (2020)

Circulating extracellular vesicles: friends and foes in neurodegeneration
por: Picca, Anna, et al.
Publicado: (2021)

Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
por: Picca, Anna, et al.
Publicado: (2020)

Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly
por: Picca, Anna, et al.
Publicado: (2023)

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles
por: Picca, Anna, et al.
Publicado: (2019)

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study
por: Picca, Anna, et al.
Publicado: (2020)

Circulating Inflammatory, Mitochondrial Dysfunction, and Senescence-Related Markers in Older Adults with Physical Frailty and Sarcopenia: A BIOSPHERE Exploratory Study
por: Picca, Anna, et al.
Publicado: (2022)

Engagement in Aerobic Exercise Is Associated with a Reduced Prevalence of Sarcopenia and Severe Sarcopenia in Italian Older Adults
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2023)

Protein-Related Dietary Parameters and Frailty Status in Older Community-Dwellers across Different Frailty Instruments
por: Coelho-Júnior, Hélio J., et al.
Publicado: (2020)

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study
por: Picca, Anna, et al.
Publicado: (2019)

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study
por: Calvani, Riccardo, et al.
Publicado: (2018)

Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies
por: Coelho-Junior, Hélio José, et al.
Publicado: (2022)

Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery
por: Picca, Anna, et al.
Publicado: (2021)

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration
por: Picca, Anna, et al.
Publicado: (2020)

Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View
por: Picca, Anna, et al.
Publicado: (2020)

Combined Aerobic Training and Mediterranean Diet Is Not Associated with a Lower Prevalence of Sarcopenia in Italian Older Adults
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2023)

Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
por: Sirago, Giuseppe, et al.
Publicado: (2022)

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study
por: Picca, Anna, et al.
Publicado: (2019)

Reply to Grant, W.B. Comment on “Coelho-Junior et al. Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients 2022, 14, 2767”
por: Coelho-Junior, Hélio José, et al.
Publicado: (2022)

Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis
por: Coelho-Junior, Hélio José, et al.
Publicado: (2022)

Extracellular Vesicles and Pancreatic Cancer: Insights on the Roles of miRNA, lncRNA, and Protein Cargos in Cancer Progression
por: Romano, Roberta, et al.
Publicado: (2021)

Circulating Mitochondrial DNA and Inter-Organelle Contact Sites in Aging and Associated Conditions
por: Picca, Anna, et al.
Publicado: (2022)

Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
por: Picca, Anna, et al.
Publicado: (2018)

Protein Intake and Frailty: A Matter of Quantity, Quality, and Timing
por: Coelho-Junior, Hélio J., et al.
Publicado: (2020)

Biomarkers for physical frailty and sarcopenia: state of the science and future developments
por: Calvani, Riccardo, et al.
Publicado: (2015)

Protein Intake and Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2021)

Anorexia of Aging: Metabolic Changes and Biomarker Discovery
por: Picca, Anna, et al.
Publicado: (2022)

Sarcopenia and Physical Frailty: Two Sides of the Same Coin
por: Cesari, Matteo, et al.
Publicado: (2014)

Low Adherence to Mediterranean Diet Is Associated with Probable Sarcopenia in Community-Dwelling Older Adults: Results from the Longevity Check-Up (Lookup) 7+ Project
por: Cacciatore, Stefano, et al.
Publicado: (2023)

Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle–Brain Axis
por: Arosio, Beatrice, et al.
Publicado: (2023)

Cell Death and Inflammation: The Role of Mitochondria in Health and Disease
por: Picca, Anna, et al.
Publicado: (2021)

Association between Dietary Habits and Physical Function in Brazilian and Italian Older Women
por: Coelho-Junior, Hélio J., et al.
Publicado: (2020)

Protein Intake Is Associated with Blood Pressure and Cholesterol Levels in Italian Older Adults: A Cross-Sectional Study
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2023)

Adherence to aerobic training combined with high protein intake is associated with low blood pressure in Italian older adults: a cross-sectional study
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2023)

Role of Age-Related Mitochondrial Dysfunction in Sarcopenia
por: Ferri, Evelyn, et al.
Publicado: (2020)

Of Microbes and Minds: A Narrative Review on the Second Brain Aging
por: Calvani, Riccardo, et al.
Publicado: (2018)

Operationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementation
por: Marzetti, E., et al.
Publicado: (2016)

Muscle power-related parameters in middle-aged and older Brazilian women: a cross-sectional study
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qqd2oufsfv7htbpdbvg2r21744