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Thioimidate Bond Formation between Cardiac Troponin C and Nitrile-containing Compounds
[Image: see text] We have investigated the mechanism and reactivity of covalent bond formation between cysteine-84 of the regulatory domain of cardiac troponin C and compounds containing a nitrile moiety similar to the calcium sensitizer levosimendan. The results of modifications to the levosimendan...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227049/ https://www.ncbi.nlm.nih.gov/pubmed/32426091 http://dx.doi.org/10.1021/acsmedchemlett.9b00168 |