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Thioimidate Bond Formation between Cardiac Troponin C and Nitrile-containing Compounds

[Image: see text] We have investigated the mechanism and reactivity of covalent bond formation between cysteine-84 of the regulatory domain of cardiac troponin C and compounds containing a nitrile moiety similar to the calcium sensitizer levosimendan. The results of modifications to the levosimendan...

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Detalles Bibliográficos
Autores principales:	Klein, Brittney A., Robertson, Ian M., Reiz, Béla, Kampourakis, Thomas, Li, Liang, Sykes, Brian D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227049/ https://www.ncbi.nlm.nih.gov/pubmed/32426091 http://dx.doi.org/10.1021/acsmedchemlett.9b00168

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