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Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study

BACKGROUND: Although ageing could increase the risk of delayed healing in diabetic foot ulcers (DFUs) patients, data from middle-aged patients remains greatly limited. The purpose of this study was to explore the clinical phenotypes, outcomes and predictive factors of DFU in middle-aged patients. ME...

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Autores principales: Tong, Tao, Yang, Cailian, Tian, Wenqing, Liu, Zhiping, Liu, Bo, Cheng, Jun, Cheng, Qingfeng, Zhou, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227070/
https://www.ncbi.nlm.nih.gov/pubmed/32414389
http://dx.doi.org/10.1186/s13047-020-00386-z
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author Tong, Tao
Yang, Cailian
Tian, Wenqing
Liu, Zhiping
Liu, Bo
Cheng, Jun
Cheng, Qingfeng
Zhou, Bo
author_facet Tong, Tao
Yang, Cailian
Tian, Wenqing
Liu, Zhiping
Liu, Bo
Cheng, Jun
Cheng, Qingfeng
Zhou, Bo
author_sort Tong, Tao
collection PubMed
description BACKGROUND: Although ageing could increase the risk of delayed healing in diabetic foot ulcers (DFUs) patients, data from middle-aged patients remains greatly limited. The purpose of this study was to explore the clinical phenotypes, outcomes and predictive factors of DFU in middle-aged patients. METHODS: A retrospective cohort study conducted with 422 consecutive inpatients with DFUs who visited our hospital between May 2010 and September 2017; participants were recruited and assigned according to age to either the middle-aged group or the elderly group. The Demographics, ulcer characteristics, comorbidities and diabetes complications, laboratory tests, socioeconomic data and final outcomes were collected. Moreover, predictive factors of adverse outcomes in middle-aged DFUs patients were assessed. RESULTS: Middle-aged patients were more likely to have worse lifestyle and glucose control, were more likely to have microangiopathy as a complication, and tended to have larger and deeper ulcers; however, these patients also had higher rates of healing and lower rates of mortality and major amputaion than elderly patients. Severe infection,living alone,current smoking cigarettes, and having a high white blood cell count were independent risk factors for adverse outcomes in middle-aged patients. CONCLUSIONS: DFUs are relatively common in middle-aged patients with diabetes, and these patients have unique clinical phenotypes and risk profiles. Nonetheless, further investigation is needed to clarify whether intervention targeting these easily recognizable risk factors can improve healing and survival rates in middle-aged DFU patients.
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spelling pubmed-72270702020-05-27 Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study Tong, Tao Yang, Cailian Tian, Wenqing Liu, Zhiping Liu, Bo Cheng, Jun Cheng, Qingfeng Zhou, Bo J Foot Ankle Res Research BACKGROUND: Although ageing could increase the risk of delayed healing in diabetic foot ulcers (DFUs) patients, data from middle-aged patients remains greatly limited. The purpose of this study was to explore the clinical phenotypes, outcomes and predictive factors of DFU in middle-aged patients. METHODS: A retrospective cohort study conducted with 422 consecutive inpatients with DFUs who visited our hospital between May 2010 and September 2017; participants were recruited and assigned according to age to either the middle-aged group or the elderly group. The Demographics, ulcer characteristics, comorbidities and diabetes complications, laboratory tests, socioeconomic data and final outcomes were collected. Moreover, predictive factors of adverse outcomes in middle-aged DFUs patients were assessed. RESULTS: Middle-aged patients were more likely to have worse lifestyle and glucose control, were more likely to have microangiopathy as a complication, and tended to have larger and deeper ulcers; however, these patients also had higher rates of healing and lower rates of mortality and major amputaion than elderly patients. Severe infection,living alone,current smoking cigarettes, and having a high white blood cell count were independent risk factors for adverse outcomes in middle-aged patients. CONCLUSIONS: DFUs are relatively common in middle-aged patients with diabetes, and these patients have unique clinical phenotypes and risk profiles. Nonetheless, further investigation is needed to clarify whether intervention targeting these easily recognizable risk factors can improve healing and survival rates in middle-aged DFU patients. BioMed Central 2020-05-15 /pmc/articles/PMC7227070/ /pubmed/32414389 http://dx.doi.org/10.1186/s13047-020-00386-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Tong, Tao
Yang, Cailian
Tian, Wenqing
Liu, Zhiping
Liu, Bo
Cheng, Jun
Cheng, Qingfeng
Zhou, Bo
Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
title Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
title_full Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
title_fullStr Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
title_full_unstemmed Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
title_short Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
title_sort phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227070/
https://www.ncbi.nlm.nih.gov/pubmed/32414389
http://dx.doi.org/10.1186/s13047-020-00386-z
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