Cargando…

Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model

BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is considered an important driver of tumor development and progression by its histone modifying capabilities. Inhibition of EZH2 activity is thought to be a potent treatment option for eligible cancer patients with an aberrant EZH2 expression profile, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akpa, Chidimma Agatha, Kleo, Karsten, Oker, Elisabeth, Tomaszewski, Nancy, Messerschmidt, Clemens, López, Cristina, Wagener, Rabea, Oehl-Huber, Kathrin, Dettmer, Katja, Schoeler, Anne, Lenze, Dido, Oefner, Peter J., Beule, Dieter, Siebert, Reiner, Capper, David, Dimitrova, Lora, Hummel, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227222/ https://www.ncbi.nlm.nih.gov/pubmed/32408898 http://dx.doi.org/10.1186/s12885-020-06937-8

Ejemplares similares

DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations
por: Akpa, Chidimma Agatha, et al.
Publicado: (2019)

Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma
por: Kleo, Karsten, et al.
Publicado: (2019)

Functional and Pathological Roles of AHCY
por: Vizán, Pedro, et al.
Publicado: (2021)

DNA methylation of AHCY may increase the risk of ischemic stroke
por: Zhao, Lei, et al.
Publicado: (2020)

Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation
por: Aranda, Sergi, et al.
Publicado: (2019)

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila
por: Parkhitko, Andrey A., et al.
Publicado: (2016)

Co-Treatment with the Epigenetic Drug, 3-Deazaneplanocin A (DZNep) and Cisplatin after DZNep Priming Enhances the Response to Platinum-Based Therapy in Chondrosarcomas
por: Lhuissier, Eva, et al.
Publicado: (2021)

Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency
por: Motzek, Antje, et al.
Publicado: (2016)

Validation and comparison of two NGS assays for the detection of EGFR T790M resistance mutation in liquid biopsies of NSCLC patients
por: Vollbrecht, Claudia, et al.
Publicado: (2018)

Determinants of Sensitivity to DZNep Induced Apoptosis in Multiple Myeloma Cells
por: Xie, Zhigang, et al.
Publicado: (2011)

Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles
por: Klopfleisch, Robert, et al.
Publicado: (2010)

Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest
por: Belužić, Lucija, et al.
Publicado: (2018)

The values of AHCY and CBS promoter methylation on the diagnosis of cerebral infarction in Chinese Han population
por: Li, Xiaodong, et al.
Publicado: (2020)

Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
por: Tong, Ling, et al.
Publicado: (2021)

Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma
por: Seitz, Volkhard, et al.
Publicado: (2011)

Exosomal circ‐AHCY promotes glioblastoma cell growth via Wnt/β‐catenin signaling pathway
por: Li, Yuhui, et al.
Publicado: (2023)

A new method to prevent carry-over contaminations in two-step PCR NGS library preparations
por: Seitz, Volkhard, et al.
Publicado: (2015)

3-Deazaneplanocin A (DZNep), an Inhibitor of S-Adenosylmethionine-dependent Methyltransferase, Promotes Erythroid Differentiation
por: Fujiwara, Tohru, et al.
Publicado: (2014)

DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
por: Sha, Mingquan, et al.
Publicado: (2015)

DZNep promotes mouse bone defect healing via enhancing both osteogenesis and osteoclastogenesis
por: Cao, Xiankun, et al.
Publicado: (2021)

Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma
por: Chicco, Davide, et al.
Publicado: (2023)

Sleep and Neurochemical Modulation by DZNep and GSK-J1: Potential Link With Histone Methylation Status
por: Murillo-Rodríguez, Eric, et al.
Publicado: (2019)

Combination of AZD3463 and DZNep Prevents Bone Metastasis of Breast Cancer by Suppressing Akt Signaling
por: He, Wenxin, et al.
Publicado: (2021)

Modulation of Allogeneic CD8(+) T-Cell Response by DZNep Controls GVHD While Preserving Hematopoietic Chimerism
por: Wang, Jina, et al.
Publicado: (2013)

Induction of macrophage-like immunosuppressive cells from common marmoset ES cells by stepwise differentiation with DZNep
por: Tsuji, Hyuma, et al.
Publicado: (2020)

EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin
por: Chen, Si-qi, et al.
Publicado: (2020)

Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes
por: Mimura, Imari, et al.
Publicado: (2018)

The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes
por: Yang, Yang, et al.
Publicado: (2022)

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)
por: Jiang, Xia, et al.
Publicado: (2015)

DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice
por: Zheng, Shijie, et al.
Publicado: (2018)

3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells
por: Girard, Nicolas, et al.
Publicado: (2014)

Histone Methylation Inhibitor DZNep Ameliorated the Renal Ischemia-Reperfusion Injury via Inhibiting TIM-1 Mediated T Cell Activation
por: Li, Jiawei, et al.
Publicado: (2020)

Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes
por: Klopfleisch, Robert, et al.
Publicado: (2012)

DigestiFlow: from BCL to FASTQ with ease
por: Holtgrewe, Manuel, et al.
Publicado: (2020)

A Compound AC1Q3QWB Selectively Disrupts HOTAIR-Mediated Recruitment of PRC2 and Enhances Cancer Therapy of DZNep
por: Li, Yansheng, et al.
Publicado: (2019)

Low-Dose 5-Aza and DZnep Alleviate Acute Graft-Versus-Host Disease With Less Side Effects Through Altering T-Cell Differentiation
por: Wang, Qing Ya, et al.
Publicado: (2022)

RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance
por: Vollbrecht, Claudia, et al.
Publicado: (2018)

Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA
por: Kumari, Kanchan, et al.
Publicado: (2018)

Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia
por: Yamazaki, Tomotaka, et al.
Publicado: (2023)

SCelVis: exploratory single cell data analysis on the desktop and in the cloud
por: Obermayer, Benedikt, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9q13jdllmqsgflkhncg3jgqn3p