Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity

BACKGROUND: Dual inhibitors of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E(2) synthase-1 (mPGES-1) may exert better anti-inflammatory efficacy and lower risks of adverse effects versus non-steroidal anti-inflammatory drugs. Despite these advantages, many dual FLAP...

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Detalles Bibliográficos
Autores principales: Shkodra-Pula, Blerina, Kretzer, Christian, Jordan, Paul M., Klemm, Paul, Koeberle, Andreas, Pretzel, David, Banoglu, Erden, Lorkowski, Stefan, Wallert, Maria, Höppener, Stephanie, Stumpf, Steffi, Vollrath, Antje, Schubert, Stephanie, Werz, Oliver, Schubert, Ulrich S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227278/
https://www.ncbi.nlm.nih.gov/pubmed/32408877
http://dx.doi.org/10.1186/s12951-020-00620-7

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