Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus

BACKGROUND: To analyze and discuss the transmission route of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV). METHOD: We performed an epidemiological investigation and a genetic analysis of patients with severe fever with thrombocytopenia syndrome (SFTS) caused b...

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Autores principales: Mao, Lingling, Deng, Baocheng, Liang, Yuhong, Liu, Yun, Wang, Zijiang, Zhang, Jie, Wu, Wei, Yu, Lei, Yao, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227288/
https://www.ncbi.nlm.nih.gov/pubmed/32410583
http://dx.doi.org/10.1186/s12879-020-05072-w
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author Mao, Lingling
Deng, Baocheng
Liang, Yuhong
Liu, Yun
Wang, Zijiang
Zhang, Jie
Wu, Wei
Yu, Lei
Yao, Wenqing
author_facet Mao, Lingling
Deng, Baocheng
Liang, Yuhong
Liu, Yun
Wang, Zijiang
Zhang, Jie
Wu, Wei
Yu, Lei
Yao, Wenqing
author_sort Mao, Lingling
collection PubMed
description BACKGROUND: To analyze and discuss the transmission route of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV). METHOD: We performed an epidemiological investigation and a genetic analysis of patients with severe fever with thrombocytopenia syndrome (SFTS) caused by SFTSV, their close contacts and the surrounding population. RESULTS: We found that all patients had contact with the blood of the first patient. The comparison of gene sequences in the three isolated SFTSV strains showed that the strains were closely related. Six close contacts and nine individuals in the surrounding population were positive for SFTSV IgM antibody. CONCLUSION: We suspect that the cluster outbreak was transmitted via blood and that the natural reservoir host of SFTSV exists in the patients’ environment.
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spelling pubmed-72272882020-05-27 Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus Mao, Lingling Deng, Baocheng Liang, Yuhong Liu, Yun Wang, Zijiang Zhang, Jie Wu, Wei Yu, Lei Yao, Wenqing BMC Infect Dis Research Article BACKGROUND: To analyze and discuss the transmission route of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV). METHOD: We performed an epidemiological investigation and a genetic analysis of patients with severe fever with thrombocytopenia syndrome (SFTS) caused by SFTSV, their close contacts and the surrounding population. RESULTS: We found that all patients had contact with the blood of the first patient. The comparison of gene sequences in the three isolated SFTSV strains showed that the strains were closely related. Six close contacts and nine individuals in the surrounding population were positive for SFTSV IgM antibody. CONCLUSION: We suspect that the cluster outbreak was transmitted via blood and that the natural reservoir host of SFTSV exists in the patients’ environment. BioMed Central 2020-05-14 /pmc/articles/PMC7227288/ /pubmed/32410583 http://dx.doi.org/10.1186/s12879-020-05072-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Mao, Lingling
Deng, Baocheng
Liang, Yuhong
Liu, Yun
Wang, Zijiang
Zhang, Jie
Wu, Wei
Yu, Lei
Yao, Wenqing
Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
title Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
title_full Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
title_fullStr Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
title_full_unstemmed Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
title_short Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
title_sort epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227288/
https://www.ncbi.nlm.nih.gov/pubmed/32410583
http://dx.doi.org/10.1186/s12879-020-05072-w
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