SRC-2 Coactivator: a role in human metabolic evolution and disease

The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifi...

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Detalles Bibliográficos
Autor principal: O’Malley, Bert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227291/
https://www.ncbi.nlm.nih.gov/pubmed/32410572
http://dx.doi.org/10.1186/s10020-020-00168-0
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author O’Malley, Bert W.
author_facet O’Malley, Bert W.
author_sort O’Malley, Bert W.
collection PubMed
description The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifically, carbohydrate, lipid, or anabolic growth metabolisms. SRC-2 is of special interest in terms of lipid metabolism and energy accrual and is the topic of a collection of our research discoveries and publications described in this Perspective.
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spelling pubmed-72272912020-05-18 SRC-2 Coactivator: a role in human metabolic evolution and disease O’Malley, Bert W. Mol Med Perspective The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifically, carbohydrate, lipid, or anabolic growth metabolisms. SRC-2 is of special interest in terms of lipid metabolism and energy accrual and is the topic of a collection of our research discoveries and publications described in this Perspective. BioMed Central 2020-05-14 /pmc/articles/PMC7227291/ /pubmed/32410572 http://dx.doi.org/10.1186/s10020-020-00168-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
O’Malley, Bert W.
SRC-2 Coactivator: a role in human metabolic evolution and disease
title SRC-2 Coactivator: a role in human metabolic evolution and disease
title_full SRC-2 Coactivator: a role in human metabolic evolution and disease
title_fullStr SRC-2 Coactivator: a role in human metabolic evolution and disease
title_full_unstemmed SRC-2 Coactivator: a role in human metabolic evolution and disease
title_short SRC-2 Coactivator: a role in human metabolic evolution and disease
title_sort src-2 coactivator: a role in human metabolic evolution and disease
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227291/
https://www.ncbi.nlm.nih.gov/pubmed/32410572
http://dx.doi.org/10.1186/s10020-020-00168-0
work_keys_str_mv AT omalleybertw src2coactivatoraroleinhumanmetabolicevolutionanddisease

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