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Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices
In the course of a day, brain states fluctuate, from conscious awake information-acquiring states to sleep states, during which previously acquired information is further processed and stored as memories. One hypothesis is that memories are consolidated and stored during “offline” states such as sle...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227438/ https://www.ncbi.nlm.nih.gov/pubmed/32457582 http://dx.doi.org/10.3389/fnsys.2020.00022 |
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author | Tukker, John J. Beed, Prateep Schmitz, Dietmar Larkum, Matthew E. Sachdev, Robert N. S. |
author_facet | Tukker, John J. Beed, Prateep Schmitz, Dietmar Larkum, Matthew E. Sachdev, Robert N. S. |
author_sort | Tukker, John J. |
collection | PubMed |
description | In the course of a day, brain states fluctuate, from conscious awake information-acquiring states to sleep states, during which previously acquired information is further processed and stored as memories. One hypothesis is that memories are consolidated and stored during “offline” states such as sleep, a process thought to involve transfer of information from the hippocampus to other cortical areas. Up and Down states (UDS), patterns of activity that occur under anesthesia and sleep states, are likely to play a role in this process, although the nature of this role remains unclear. Here we review what is currently known about these mechanisms in three anatomically distinct but interconnected cortical areas: somatosensory cortex, entorhinal cortex, and the hippocampus. In doing so, we consider the role of this activity in the coordination of “replay” during sleep states, particularly during hippocampal sharp-wave ripples. We conclude that understanding the generation and propagation of UDS may provide key insights into the cortico-hippocampal dialogue linking archi- and neocortical areas during memory formation. |
format | Online Article Text |
id | pubmed-7227438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72274382020-05-25 Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices Tukker, John J. Beed, Prateep Schmitz, Dietmar Larkum, Matthew E. Sachdev, Robert N. S. Front Syst Neurosci Neuroscience In the course of a day, brain states fluctuate, from conscious awake information-acquiring states to sleep states, during which previously acquired information is further processed and stored as memories. One hypothesis is that memories are consolidated and stored during “offline” states such as sleep, a process thought to involve transfer of information from the hippocampus to other cortical areas. Up and Down states (UDS), patterns of activity that occur under anesthesia and sleep states, are likely to play a role in this process, although the nature of this role remains unclear. Here we review what is currently known about these mechanisms in three anatomically distinct but interconnected cortical areas: somatosensory cortex, entorhinal cortex, and the hippocampus. In doing so, we consider the role of this activity in the coordination of “replay” during sleep states, particularly during hippocampal sharp-wave ripples. We conclude that understanding the generation and propagation of UDS may provide key insights into the cortico-hippocampal dialogue linking archi- and neocortical areas during memory formation. Frontiers Media S.A. 2020-05-08 /pmc/articles/PMC7227438/ /pubmed/32457582 http://dx.doi.org/10.3389/fnsys.2020.00022 Text en Copyright © 2020 Tukker, Beed, Schmitz, Larkum and Sachdev. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tukker, John J. Beed, Prateep Schmitz, Dietmar Larkum, Matthew E. Sachdev, Robert N. S. Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices |
title | Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices |
title_full | Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices |
title_fullStr | Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices |
title_full_unstemmed | Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices |
title_short | Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices |
title_sort | up and down states and memory consolidation across somatosensory, entorhinal, and hippocampal cortices |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227438/ https://www.ncbi.nlm.nih.gov/pubmed/32457582 http://dx.doi.org/10.3389/fnsys.2020.00022 |
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